Search for dissertations about: "gastrointestinal tract oral drug"

Showing result 1 - 5 of 11 swedish dissertations containing the words gastrointestinal tract oral drug.

2. 1. Oral delivery of macromolecules formulated with permeation enhancers

   Author : Staffan Berg; Christel Bergström; Nigel Davies; Andreas Hugerth; David Brayden; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oral peptide delivery; permeation enhancer; sodium caprate; oral drug delivery; intestinal absorption of macromolecules; Biofarmaci; Biopharmaceutics; Galenisk farmaci; Pharmaceutics;

   Abstract : Therapeutic macromolecules including peptides, proteins, and nucleotide-based ones (such as antisense oligonucleotides and RNAs) have great potential as drug candidates. One drawback is that they typically need to be administered parenterally via subcutaneous, intramuscular or intravenous injections. READ MORE

4. 2. Ecological disturbances and emergence of resistance in the oral and gastrointestinal microflora after drug exposure

   Author : Christina Stark; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ecology antimicrobial resistance oral gastrointestinal microflora B-lactamase enzyme induction.;

   Abstract : The exposure of antimicrobial agents and antacids may disturb the ecological balance of the normal microflora. This influence often leads to decreased colonization resistance due to repression of sensitive bacteria and selection of resistant bacteria which have acquired resistance during therapy. READ MORE

5. 3. Improved Molecular Understanding of Lipid-Based Formulations : for Enabling Oral Delivery of Poorly Water-Soluble Drugs

   Author : Linda C. Alskär; Christel Bergström; Brendan Griffin; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lipid-based formulation; poorly water-soluble drug; solubility prediction; molecular properties; lipid digestion; precipitation; solid state; intestinal solubilization; in vitro in vivo correlation IVIVC ; coadministration; Farmaceutisk vetenskap; Pharmaceutical Science;

   Abstract : The majority of emerging drug candidates are not suited for conventional oral dosage forms, as they do not dissolve in the aqueous environment of the gastrointestinal (GI) tract. Consequently, a large number of enabling formulation strategies have emerged. READ MORE

6. 4. Faecal Calprotectin Diagnostics : Focus on Primary Care and Suspected Sources of Error

   Author : Zlatica Rendek; Henrik Hjortswang; Magnus Falk; Ewa Grodzinsky; Stergios Kechagias; Mikael Lilja; Linköpings universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Calprotectin; Inflammatory bowel disease; Gastrointestinal disease; Primary health care; Non-steroidal anti-inflammatory agents; Proton pump inhibitors; Respiratory tract infection;

   Abstract : Patients with gastrointestinal symptoms often present a diagnostic challenge for general practitioners. Faecal calprotectin (FC) is commonly used as a marker of intestinal inflammation and is useful for differentiating between inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), as well as for the follow-up of patients with IBD and monitoring treatment response. READ MORE

7. 5. Clinical Pharmacokinetics of Small Doses of Ethanol : Role of Gastric Emptying and Other Influences in the Upper Gastrointestinal Tract

   Author : Stergios Kechagias; Risto Roine; Linköpings universitet; []
   Keywords : MEDICINE; MEDICIN;

   Abstract : This thesis deals with the clinical pharmacokinetics of small doses of ethanol as influenced by conditions in the proximal gut. The bioavailability of orally administered ethanol depends to a large extent on gastric emptying, which is influenced by pre-treatment with drugs and other clinically relevant factors in the upper gastrointestinal tract. READ MORE