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Showing result 1 - 5 of 216 swedish dissertations matching the above criteria.

  2. 1. Evolving the Methodology for Detection of Primary DNA Damage : Development, adaptation and assessment of the single cell gel electrophoresis (comet) assay

    Author : Erik Bivehed; Björn Hellman; Hanna Karlsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Comet assay; DNA damage; DNA strand breaks; Flash-comet; Genotoxicity; In vitro; Single cell gel electrophoresis; Polymerase assisted DNA damage assay PADDA ; TK6 cells; UCDAS; U937 cells; Toxikologi; Toxicology; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : Deoxyribonucleic acid (DNA) is one of the most important molecules in nature. It is the fundamental carrier of evolutionary information and constitutes the genetic blueprint of all living organisms. Being the sole source of information, it is vital for the cell to transmit the correct genetic information from generation to generation. READ MORE

  4. 2. Concatemerization of Synthetic Oligonucleotides, Assembly on Surface and Ligand Interactions

    Author : Lu Sun; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; DNA formation; DNA concatemer; self-assemble; gel electrophoresis; DNA-binding; hybridization; QCM-D;

    Abstract : DNA nanotechnology has become an important research field because of its advantages in high predictability and accuracy of base-paring recognition. DNA concatemer, one of the simplest DNA constructs in shape, have been found as efficient signal amplifiers in several biosensors for different applications. READ MORE

  5. 3. Formation and Characterization of DNA Concatemers for Single Molecule Mechanism Studies

    Author : Lu Sun; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; concatemers; hybridization; DNA; gel electrophoresis; self-assembly; constructs; nanotechnology;

    Abstract : Well known as genetic information carrier, DNA however, in the past three decade experienced a revolution to become a fashionable fabrication material in nanotechnology as a consequence of the high predictability and accuracy of base-paring recognition. Although DNA can be constructed in many fancy 2D and 3D structures, this thesis work focused on constructing one-dimension linear DNA concatemers in order to study sequence specific DNA-ligand binding at the single-molecule level. READ MORE

  6. 4. Concatemerization of Synthetic Oligonucleotides

    Author : Lu Sun; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; gel electrophoresis; DNA-binding; QCM-D; DNA concatemer; hybridization; DNA formation; self-assembly;

    Abstract : DNA nanotechnology has become an important research field because of its advantages in high predictability and accuracy of base-paring recognition. For example, the DNA concatemer, one of the simplest DNA constructs in shape, has been used to enhance signals in biosensing. READ MORE

  7. 5. In vitro and in vivo studies of salivary films at solid/liquid interfaces

    Author : Ida Svendsen; Malmö högskola; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; saliva; proteins; adsorption; ellipsometry; gel electrophoresis;

    Abstract : A conditioning film, the pellicle, of which many salivary proteins areimportant constituents, covers the surfaces present in the mouth. The pellicleforms in a selective adsorption process, and it has protective and lubricatingfunctions as well as an influence on the adherence of oral microbes thatultimately leads to the development of dental plaque. READ MORE