Search for dissertations about: "gel-phase"

Showing result 1 - 5 of 22 swedish dissertations containing the word gel-phase.

2. 1. Solid-phase glycoconjugate synthesis : on-resin analysis with gel-phase ¹9F NMR spectroscopy

   Author : Mickael Mogemark; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Solid-phase synthesis; protective groups; linkers; monitoring; gel-phase; 19F NMR spectroscopy; carbohydrates; oligosaccharides; glycopeptides; Organisk kemi; Organic chemistry; Organisk kemi;

   Abstract : An efficient and versatile non-destructive method to analyze the progress of solid-phase glycoconjugate synthesis with gel-phase 19F NMR spectroscopy is described. The method relies on use of fluorinated linkers and building blocks carrying fluorinated protective groups. READ MORE

4. 2. Thermodynamics and Structure of Plate-Like Particle Dispersions

   Author : Maxime Delhorme; Beräkningskemi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Charge anisotropy; Gel phase; Model clay system; Liquid-crystal phases; Plate-like particles; Simulations; Statistical mechanics;

   Abstract : A considerable amount of mineral particles are found to have a plate-like shape. The work in this thesis concerns theoretical investigations, using Monte Carlo method, of the properties of such particles in aqueous solutions. READ MORE

5. 3. Antigens derived from the mucin MUC1 : Solution and solid-phase synthesis of saccharides, peptides and glycopeptides

   Author : Maciej Pudelko; Mikael Elofsson; Fredrik Almqvist; Thisbe K. Lindhorst; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Lactones; glycopeptides; signal peptide; neoglycolipid arrays; solid-phase synthesis; MUC1; gel-phase 19F NMR spectroscopy; fluorinated alpha-amino protective group; Organic chemistry; Organisk kemi;

   Abstract : Mucin is a term used to describe a large family of heavily glycosylated proteins which are present on the surfaces of secretory epithelial cells and are overexpressed by many carcinomas. Membrane-bound mucin MUC1 is of special interest. Its backbone consists of repeating units of twenty amino acids with five potential glycosylation sites. READ MORE

6. 4. Glycoconjugates : Solid-phase synthesis and biological applications

   Author : Fredrik Wallner; Mikael Elofsson; Jan Kihlberg; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Glycoconjugate; Glycolipid; Solid-phase synthesis; Glycosylation; Gel-phase 19F-NMR spectroscopy; Fluorinated linker; Carbohydrat array; CD1; Organic chemistry; Organisk kemi;

   Abstract : Glycoconjugates are biologically important molecules with diverse functions. They consist of carbohydrates of varying size and complexity, attached to a non-sugar moiety as a lipid or a protein. Glycoconjugate structures are often very complex and their intricate biosynthetic pathways makes overexpression difficult. READ MORE

7. 5. Glycoconjugates : synthesis and investigation of carbohydrate-protein interactions

   Author : Sara Spjut; Mikael Elofsson; Ulf Ellervik; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Glycoconjugates; Carbohydrates; Galactose; Glucose; Solid-phase synthesis; SPOS; Glycosylation; Gel-phase 19F NMR spectroscopy; Fluorinated linker; Carbohydrate array; Microtiter plates; Carbohydrate-protein interactions; carbamate linker; Fsec; Protecting group; Fluorinated protecting group; Multivalent glycoconjugates; Adenovirus; Ad37; Epidemic keratoconjunctivitis; EKC; Sialic acid; Adenovirus inhibitor; Trivalent; Tetravalent; X-ray crystal structure; Bioorganic chemistry; Bioorganisk kemi; organisk kemi; Organic Chemistry;

   Abstract : To study the functions of glycoconjugates in biological systems reliable and efficient protocols for glycoconjugate synthesis are needed. To reach this goal we have developed methods for solid-phase synthesis of glycoconjugates that can be monitored with gel-phase 19F spectroscopy using fluorinated linkers, building blocks, and protecting groups. READ MORE