Search for dissertations about: "gene amplification"

Showing result 21 - 25 of 225 swedish dissertations containing the words gene amplification.

  2. 21. Mining the transcriptome - methods and applications

    Author : Valtteri Wirta; Joakim Lundeberg; John Quackenbush; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; transcriptome; gene expression profiling; EST; microarray; RNA amplification; stem cells; neurosphere; Genetic engineering including functional genomics; Genteknik inkl. funktionsgenomik;

    Abstract : Regulation of gene expression occupies a central role in the control of the flow of genetic information from genes to proteins. Regulatory events on multiple levels ensure that the majority of the genes are expressed under controlled circumstances to yield temporally controlled, cell and tissue-specific expression patterns. READ MORE

  4. 22. Somatic Mutations in Breast Cancer Genomes : Discovery and Validation of Breast Cancer Genes

    Author : Xiang Jiao; Tobias Sjöblom; Anne-Lise Børresen-Dale; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; breast cancer; cancer gene; pathway; somatic mutation; structural alteration; sequencing; whole genome amplification; Genetics; Genetik; Medical Genetics; Medicinsk genetik;

    Abstract : Breast cancer is the most common cancer in women worldwide. However, the genetic alterations that lead to breast cancer are not fully understood. This thesis aims to identify novel genes of potential mechanistic, diagnostic or therapeutic interest in breast cancers by mutational analysis and whole-genome sequencing. READ MORE

  5. 23. Interpreting the human transcriptome

    Author : Beata Werne Solnestam; Joakim Lundeberg; Piero Carninci; KTH; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Transcriptome; RNA sequencing; high-throughput sequencing; gene expression profiling; multiplex amplification; Bioteknologi; Biotechnology;

    Abstract : The human body is made of billions of cells and nearly all have the same genome. However, there is a high diversity of cells, resulted from what part of the genome the cells use, i.e. which RNA molecules are expressed. READ MORE

  6. 24. Massively parallel analysis of cells and nucleic acids

    Author : Julia Sandberg; Joakim Lundeberg; Nader Pourmand; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Massively parallel sequencing; 454; Illumina; multiplex amplification; whole genome amplification; single cell; polyguanine; flow-cytometry;

    Abstract : Recent proceedings in biotechnology have enabled completely new avenues in life science research to be explored. By allowing increased parallelization an ever-increasing complexity of cell samples or experiments can be investigated in shorter time and at a lower cost. READ MORE

  7. 25. Consequences of the Domestication of Man’s Best Friend, The Dog

    Author : Susanne Björnerfeldt; Carles Vilà; Elena Jazin; Daniel Bradley; Uppsala universitet; []
    Keywords : Molecular genetics; mitochondrial genome; Y chromosome; microsatellites; disruptive selection; breed structure; whole genome amplification; gene flow; linkage disequilibrium; Canis familiaris; Canis lupus; Genetik;

    Abstract : The dog was the first animal to be domesticated and the process started at least 15 000 years ago. Today it is the most morphologically diverse mammal, with a huge variation in size and shape. READ MORE