Search for dissertations about: "gene discovery"

Showing result 21 - 25 of 233 swedish dissertations containing the words gene discovery.

  2. 21. Network-based biomarker discovery for multiple sclerosis

    Author : Julia Åkesson; Mika Gustafsson; Zelmina Lubovac-Pilav; Lukas Käll; Linköpings universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : Complex autoimmune diseases, such as multiple sclerosis (MS), develop as a result of perturbations in the regulatory system controlling the function of immune cells. The disease course of MS is heterogeneous but is characterised by chronic inflammation in the central nervous system causing neurodegeneration resulting in gradual disability worsening. READ MORE

  4. 22. Statistical methods for biomarker discovery in proteomics

    Author : Chuen Seng Tan; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Proteomics; mass spectrometry; SELDI; MALDI; peak detection; signal detection; peak annotation; transcriptomics; data integration; maximum covariance analysis; generalized singular value decomposition;

    Abstract : Surface-Enhanced Laser Desorption and Ionization (SELDI) is a promising proteomic technique for discovering biomarkers. However, the pre-processing of the raw data is still problematic. READ MORE

  5. 23. Genetic Aspects of Endocrine Tumorigenesis : A Hunt for the Endocrine Neoplasia Gene

    Author : Alberto Delgado Verdugo; Peyman Björklund; gunnar westin; Per Hellman; Filip Farnebo; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Exome sequencing; SDHAF2; epigenetics; methylation; methylation array; Sanger sequencing; pheochromocytoma; SI-NETs; carcinoid; oncology; endocrine surgery; parathyroid; Genetics; Genetik; Kirurgi; Surgery;

    Abstract : Endocrine tumors arise from endocrine glands. Most endocrine tumors are benign but malignant variants exist. Several endocrine neoplasms display loss of parts of chromosome 11 or 18, produce hormones and responds poorly to conventional chemotherapeutics. The multiple endocrine neoplasia syndromes are mainly confined to endocrine tumors. READ MORE

  6. 24. Molecular Screening for Target Discovery in Cancer

    Author : Mårten Fryknäs; Anders Isaksson; Ulf Pettersson; Hugh Salter; Uppsala universitet; []
    Keywords : Genetics; Cancer; Drug resistance; Microarray; High-throughput screening; Genetik;

    Abstract : Cancer is one of the major causes of death in the western world. Resistance to anti-cancer drugs and diagnostic difficulties are major obstacles to successful treatment. READ MORE

  7. 25. Biomarker Discovery in Tissue-specific Autoimmune Disease

    Author : Nils Landegren; Olle Kämpe; Björn Dahlbäck; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Autoimmune diseases encompass a diverse group of disorders that collectively affect 5% of the population. Despite large clinical variability, autoimmune disorders share a common etiology in that they all develop from immune responses against self. READ MORE