Search for dissertations about: "gene network analysis"
Showing result 16 - 20 of 134 swedish dissertations containing the words gene network analysis.
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16. Metabolic Modeling of the Gut Microbiome-Host Interactions and Meta’omics Integration
Abstract : A large number of microbes with different strain types occupy the human gut. These gut inhabitant microbes have key roles in decomposition of indigestible dietary macronutrients before they are metabolised by the host. READ MORE
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17. Identification of new disease mechanisms and treatments for type 2 diabetes based on genetic variants and gene expression networks
Abstract : Improved understanding of the disease mechanisms underlying type 2 diabetes (T2D) is needed, and so are new treatments.A new T2D risk variant was recently identified in ADRA2A, which encodes the α2A-adrenergic receptor. READ MORE
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18. Graph theory based approaches for gene prioritization in biological networks : Application to cancer gene detection in medulloblastoma
Abstract : Networks provide an intuitive and highly adaptable means to model relationships between objects. When translated to mathematical graphs, they become further amenable to a plethora of mathematical operations that allow a detailed study of the underlying relational data. READ MORE
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19. Gene Expression in mESC Deficient in FGFR Signalling and the Identification of the Novel Gene Ened
Abstract : Embryonic stem cells (ESCs) are derived from the inner cell mass (ICM) of blastocyst stage embryos, and upon differentiation into embryoid bodies (EBs) they recapitulate the genetic, cellular and morphological events occurring in early embryogenesis. Among several signalling pathways and inductive factors, the fibroblast growth factors (FGFs) and their receptors (FGFRs) have been shown to be important during early embryogenesis. READ MORE
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20. Data integration for robust network-based disease gene prediction
Abstract : For many complex diseases the cause/mechanism can be tied not to a single gene and in order to cope with the complexity a systems wide approach is needed. By combining evidence indicative of functional association it is possible to infer networks of protein functional coupling. READ MORE