Search for dissertations about: "gene polymorphism"

Showing result 6 - 10 of 455 swedish dissertations containing the words gene polymorphism.

  2. 6. A Genetic Survey of the Pathogenic Parasite Trypanosoma cruzi

    Author : Anh-Nhi Tran; Lena Åslund; John Kelly; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular genetics; Trypanosoma cruzi; Chagas ; gene discovery; EST; sequencing; DGC3; repeats; gene family; CL Brener; trypanothione synthetase; TcTRS locus; alleles; polymorphism; RNA-binding protein; TcPTB; stage-specific expression; Genetik; Genetics; Genetik; medicinsk genetik; Medical Genetics;

    Abstract : Trypanosoma cruzi, the causative agent of Chagas´ disease, is an evolutionarily ancient species with distinct biological and immunological characteristics. A fundamental understanding of the basic biology of the parasite is necessary in order to develop reliable therapeutic and prophylactic agents against T. cruzi. We have, as a part of the T. READ MORE

  4. 7. Reward-related genes and alcohol dependence

    Author : Sara Landgren; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; alcohol; dependence; reward; smoking; body weight; gene; polymorphism; nAChR; ghrelin; GHS-R1A;

    Abstract : Introduction: The rewarding properties of alcohol are mediated by the brain reward systems, specifically by the cholinergic-dopaminergic reward link, involving both nicotinic acetylcholine receptors (nAChRs) as well as the ghrelin signalling system. The susceptibility for developing alcohol dependence is influenced by genetic factors. READ MORE

  5. 8. On the Tissue-type Plasminogen Activator (t-PA) -7,351C>T Enhancer Polymorphism. Importance for endothelial t-PA gene expression and arterial thrombotic disease

    Author : Anna Tjärnlund-Wolf; Göteborgs universitet; []
    Keywords : tissue-type plasminogen activator; plasminogen activator inhibitor type-1; polymorphism; endothelium; Sp1; gene expression; myocardial infarction; ischemic stroke;

    Abstract : Local endothelial release of tissue-type plasminogen activator (t-PA) is an important thromboprotective mechanism. Earlier work by our group has identified a common single nucleotide polymorphism (SNP) at the t-PA locus (-7,351C>T), located within a GC-box in the retinoic acid (RA) and steroid hormone responsive t-PA enhancer. READ MORE

  6. 9. Exploring the Realm of Gene Expression Differences Between White Leghorn and Red Junglefowl Chickens

    Author : Carolyn Fitzsimmons; Leif Andersson; Finn Hallböök; Dave Burt; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular genetics; chicken; gene expression; microarray; polymorphism; Genetik; Genetics; Genetik;

    Abstract : In this thesis we attempted to elicit patterns of gene expression that influence phenotype, and that may also have been altered by thousands of years of domestication and selection, between red junglefowl and White Leghorn chickens. Red junglefowl are the wild ancestor to all domesticated chickens, and poultry in general are highly valued as a research animal and food resource. READ MORE

  7. 10. Functional characterisation of the CAG polymorphism in the androgen receptor- in vitro and in vivo

    Author : Hannah Nenonen; Diabetes - öpatofysiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; androgen receptor; polymorphism; CAG polymorphism; androgen receptor activity; infertility; prostate cancer; androgen receptor function;

    Abstract : The androgen receptor (AR) is the mediator of androgen actions. In the AR coding region there is a polymorphic CAG repeat encoding a stretch of the amino acid glutamine (Q). The repeat length modulates receptor activity and is normally distributed between 10-30 CAG with a median length of 22 repeats in white men. READ MORE