Search for dissertations about: "gene synthesis"

Showing result 1 - 5 of 465 swedish dissertations containing the words gene synthesis.

  2. 1. Organization of mitochondrial gene expression in yeast : Specific features of organellar protein synthesis

    Author : Kirsten Kehrein; Martin Ott; Thomas A Fox; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Mitochondria; translation; bc1 complex; ribosome; gene expression; Biochemistry; biokemi;

    Abstract : Mitochondria contain their own genetic system, encoding key subunits of the oxidative phosphorylation system. These subunits are expressed by an organelle-specific gene expression machinery. READ MORE

  4. 2. Chimeric gene delivery vectors : Design, synthesis, and mechanisms from transcriptomics analysis

    Author : Moataz Dowaidar; Ülo Langel; Sandrine Sagan; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell-penetrating peptides; magnetic nanoparticles; graphene oxide; autophagy; siRNA; SCO; QSAR; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : Delivery of nucleic acid is a promising approach for genetic diseases/disorders. However, gene therapy using oligonucleotides (ONs) suffers from low transfection efficacy due to negative charges, weak cellular permeability, and enzymatic degradation. READ MORE

  5. 3. Functional Cyclic Carbonate Monomers and Polycarbonates : Synthesis and Biomaterials Applications

    Author : Jonas Mindemark; Tim Bowden; Andrew Dove; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; DNA condensation; gene delivery; ionomers; polyplexes; self-assembly; amphiphiles; biodegradable; biological applications of polymers; transfection; cyclic carbonate monomers; polycarbonates; semicrystalline polymers; click chemistry; triazoles; cycloaddition; Kemi med inriktning mot polymerkemi; Chemistry with specialization in Polymer Chemistry;

    Abstract : The present work describes a selection of strategies for the synthesis of functional aliphatic polycarbonates. Using an end-group functionalization strategy, a series of DNA-binding cationic poly(trimethylene carbonate)s was synthesized for application as vectors for non-viral gene delivery. READ MORE

  6. 4. Genetics of Tetrapyrrole Synthesis in Gram-Positive Bacteria

    Author : Per Johansson; Biologiska institutionen; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Microbiology; siroheme; tetrapyrrole synthesis; Bacillus subtilis; Bacillaceae; bacteriology; virology; mycology; Mikrobiologi; bakteriologi; virologi; mykologi;

    Abstract : The organization and regulation of genes for tetrapyrrole synthesis were studied in low G+C Gram-positive bacteria. Clusters of genes encoding enzymes for tetrapyrrole biosynthesis were cloned from Bacillus sphaericus, Bacillus stearothermophilus, Brevibacillus brevis and Paenibacillus macerans. READ MORE

  7. 5. Novel methods to study mitochondrial gene expression and homeostasis

    Author : Magdalena Rzepka; Martin Ott; Christof Osman; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; mitochondria; gene expression; metabolism; biokemi; Biochemistry;

    Abstract : Mitochondria are semi-autonomous organelles that harbor one of the main cellular processes – energy conversion. Nutrients available in the environment are taken up by cells and transformed into metabolites that can be used for synthesis of ATP, the energy currency of the cell. READ MORE