Search for dissertations about: "gene variants"
Showing result 16 - 20 of 585 swedish dissertations containing the words gene variants.
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16. Statistical methods for detecting gene-gene and gene-environment interactions in genome-wide association studies
Abstract : Despite considerable effort to elucidate the genetic architecture of multi-factorial traits and diseases, there remains a gap between the estimated heritability (e.g., from twin studies) and the heritability explained by discovered genetic variants. READ MORE
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17. Reward-related genes and alcohol dependence
Abstract : Introduction: The rewarding properties of alcohol are mediated by the brain reward systems, specifically by the cholinergic-dopaminergic reward link, involving both nicotinic acetylcholine receptors (nAChRs) as well as the ghrelin signalling system. The susceptibility for developing alcohol dependence is influenced by genetic factors. READ MORE
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18. Underlying genetic mechanisms of hereditary dystrophies in retina and cornea
Abstract : Inherited retinal and corneal dystrophies represent a group of disorders with great genetic heterogeneity. Over 250 genes are associated with retinal diseases and 16 genes are causative of corneal dystrophies. READ MORE
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19. Inflammasome polymorphisms and the Inflammatory Response to Bacterial Infections
Abstract : NLRP3 inflammasome; a key component of the innate immune system, can be activated by a number of pathogens and other threats of the body. Activation of the NLRP3 inflammasome triggers caspase-1 mediated maturationof IL-1β and IL-18. READ MORE
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20. Reproductive isolation at contact zones
Abstract : Speciation is among the most important evolutionary processes that contribute to biodiversity. It involves the formation of new species that have become reproductively isolated through a process that is not linear and varies in time and space. READ MORE