Search for dissertations about: "general pulmonary distribution model"

Found 2 swedish dissertations containing the words general pulmonary distribution model.

2. 1. Novel Pharmacometric Methods for Informed Tuberculosis Drug Development

   Author : Oskar Clewe; Ulrika S.H. Simonsson; Mats O. Karlsson; Piet van der Graaf; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics; pharmacodynamics; PKPD; pharmacometric; nonlinear mixed-effects models; multistate tuberculosis pharmacometric model; general pharmacodynamic interaction model; general pulmonary distribution model; tuberculosis; rifampicin; isoniazid; ethambutol; Pharmaceutical Science; Farmaceutisk vetenskap;

   Abstract : With approximately nine million new cases and the attributable cause of death of an estimated two millions people every year there is an urgent need for new and effective drugs and treatment regimens targeting tuberculosis. The tuberculosis drug development pathway is however not ideal, containing non-predictive model systems and unanswered questions that may increase the risk of failure during late-phase drug development. READ MORE

4. 2. Ventilation/Perfusion Matching and its Effect on Volatile Pharmacokinetics

   Author : Moritz Andreas Kretzschmar; Anders Larsson; Jan Jakobsson; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anesthesia; Animal models in research; Mass spectrometry; Gas chromatography; MIGET; Ventilation-perfusion; Desflurane; Isoflurane; Bronchoconstriction; Anestesiologi och intensivvård; Anaesthesiology and Intensive Care;

   Abstract : The mismatching of alveolar ventilation and perfusion (VA/Q) is the major determinant of impaired gas exchange. The gold standard for analyzing VA/Q distribution is the multiple inert gas elimination technique (MIGET), conventionally based on gas chromatography (GC), and, although simple in principle, a technically demanding procedure limiting its use. READ MORE