Search for dissertations about: "generation of dopamine neurons"
Showing result 1 - 5 of 29 swedish dissertations containing the words generation of dopamine neurons.
-
1. Generation of Dopaminergic Neurons from Human Embryonic Stem Cells
Abstract : Since the first successful derivation of human embryonic stem cells (hESC), rapid progress has been attained in the development of strategies in differentiation of these cells into various neural lineages, with the fundamental objective of using these cells for replacement and repair of damaged neuronal circuits in the central nervous system (CNS). Of particular interest are midbrain dopaminergic (mDA) neurons, which play a central role in regulation of voluntary movement. READ MORE
-
2. Generation of midbrain dopaminergic neurons in vivo and in vitro: the role of Neurogenin2
Abstract : Parkinsons disease (PD) is a neurodegenerative disorder where dopaminergic neurons of the substantia nigra (SNc) in the mesencephalon are progressively eliminated. The ensuing loss of dopaminergic innervation of the basal ganglia manifests itself as severe motor deficits in PD patients. READ MORE
-
3. On the influence of dopamine-related genetic variation on dopamine-related disorders
Abstract : Rationale: Dopamine synthesizing neurons are involved in a wide variety of functions. The most prominent dopamine pathways originate in the midbrain. The development, function and survival of these dopaminergic neurons are under the influence of numerous transcription and neurotrophic factors. READ MORE
-
4. Up-regulation of dopamine D₂ receptors : in vitro and in vivo studies
Abstract : In the central nervous system (CNS) dopaminergic and dopaminoceptive neurons have the ability to respond to variations in dopamine levels by for example adjusting their dopamine receptor levels. One of the most well known phenomena in this respect is that long-term blockade of D2 receptors with antipsychotic drugs leads to an increase in striatal D2 receptor density of experimental animals as well as of schizophrenic patients as measured in both post-mortem studies and in vivo positron emission tomography studies of brain. READ MORE
-
5. Generation of dopamine neurons in vivo and from embryonic stem cells in vitro
Abstract : Mesencephalic dopamine (mesDA) neurons degenerate in patients with Parkinson s disease. In order to develop new treatment strategies for rescuing or replacing degenerating mesDA neurons, an improved understanding of the development and survival of these neurons in the normal brain is required. READ MORE