Search for dissertations about: "genes in glioblastoma multiforme thesis"

Showing result 1 - 5 of 11 swedish dissertations containing the words genes in glioblastoma multiforme thesis.

  2. 1. Modeling glioblastoma heterogeneity to decipher its biology

    Author : Yuan Xie; Lene Uhrbom; Massimo Squatrito; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glioblastoma multiforme; biobank; GBM cells; cell of origin; LGR5; OPCs;

    Abstract : Glioblastoma multiforme (GBM) is the most common and lethal form of primary brain tumor that mainly affects adults. GBM displays remarkable intra- and inter-tumoral heterogeneity and contains a subpopulation of cells named glioma stem cells that is believed to be responsible for tumor maintenance, progression and recurrence. READ MORE

  4. 2. Screening for Candidate Brain Tumor Genes : Identifying Genes that Cooperate with Platelet-Derived Growth Factor in Glioma Development and Progression

    Author : Fredrik Johansson; Bengt Westermark; Leif Carlsson; Uppsala universitet; []
    Keywords : Pathology; PDGF; insertional mutagenesis; retroviral tagging; common insertion site; glioma; expression; cGMP-dependent protein kinase II; Patologi;

    Abstract : Malignant primary brain tumors, gliomas, often overexpress both platelet-derived growth factor (PDGF) ligands and receptors providing an autocrine and/or paracrine boost to tumor growth. Glioblastoma multiforme (GBM) is the most frequent glioma. Its aggressive and infiltrative growth renders it extremely difficult to treat. READ MORE

  5. 3. Identification of novel genes with important functions in glioblastoma multiforme and acute myeloid leukemia

    Author : Aditya Harisankar; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Glioblastoma multiforme (GBM) is one of the most common and aggressive brain tumors. The cancer stem cells of GBM (GSCs) are notorious for being invasive as well as resistant to radiation and chemotherapy. The current treatment options for GBM lack specificity and result in severe side effects. READ MORE

  6. 4. Gene expression studies in human astrocytoma, with emphasis on oncostatin M induced effects

    Author : Annika Krona; Göteborgs universitet; []
    Keywords : Brain tumors; astrocytoma; glioblastoma multiforme; oncostatin M OSM ; STAT; microarray;

    Abstract : Brain tumors comprise about one percent of all cancers and astrocytoma is the most common primary brain malignancy. According to the World Health Organization system, the astrocytomas are divided into four grades according to degree of malignancy. Grade I, pilocytic astrocytoma (PA), is the least malignant form and most often affects children. READ MORE

  7. 5. The LRIG-family: identification of novel regulators of ErbB signaling with clinical implications in astrocytoma

    Author : Jonas Nilsson; Håkan Hedman; Roger Henriksson; Maria Sibilia; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; astrocytic tumors; EGFR; ErbB; glioblastoma multiforme; LRIG; negative regulation.; Oncology; Onkologi;

    Abstract : Astrocytic tumors are the most common malignancies of the central nervous system, accounting for more than 60% of all primary brain tumors. The prognosis for high grade astrocytoma patients is dismal and there is no curative treatment, today. READ MORE