Search for dissertations about: "genetic architecture"
Showing result 1 - 5 of 93 swedish dissertations containing the words genetic architecture.
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1. Understanding the genetic basis of complex traits
Abstract : Recent advances in genetics and genomics have provided numerous opportunities to study the genetic basis of complex traits. Nevertheless, dissecting the genetic basis of complex traits is still challenged by the complex genetic architecture, in which many genes are involved, and many have small contributions to phenotypic variation, interactions with other genes or environmental factors. READ MORE
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2. The genetic architecture of sexual dimorphism
Abstract : Phenotypic differences between the sexes evolve largely because selection favours a different complement of traits in either sex. Theory suggests that, despite its frequency, sexual dimorphism should be generally constrained from evolving because the sexes share much of their genome. READ MORE
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3. Understanding the genetic architecture of fatty liver disease
Abstract : Non-alcoholic fatty liver disease (NAFLD) is currently the most common chronic liver disease, ranging from simple steatosis to more severe conditions, namely non-alcoholic steatohepatitis (NASH), liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). NAFLD has a strong genetic component, and its heritability depends on environmental factors and ethnicity. READ MORE
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4. Dissecting the Genetic Basis of Systemic Lupus Erythematosus : The Pursuit of Functional Variants
Abstract : Systemic lupus erythematosus (SLE) is a chronic and systemic autoimmune disease that primarily affects women during the childbearing years. SLE is characterized by the production of autoantibodies against nucleic acids and their interacting proteins. READ MORE
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5. Evolutionary Materialism: Towards a Theory of Anticipatory Adaptive Assemblages
Abstract : This thesis is an investigation into how meta-heuristic multi-objective optimisation processes (genetic algorithms driven by evolutionary solvers) can bring about materials-related advantages in architectural performance. It redefines the architect’s and engineer’s role from being designers of a singular space or structure to being designers of entire species of spaces, and discusses a particular method – anticipatory adaptive assemblages (AAA) – that allows such processes to produce many generations of design iterations that eventually yield individuals optimised for a set of predefined objectives. READ MORE