Search for dissertations about: "genetic cancer in vivo and in vitro"

Showing result 1 - 5 of 54 swedish dissertations containing the words genetic cancer in vivo and in vitro.

  2. 1. MicroRNA expression profiles in prostate cancer bone metastases : functional effects of microRNA-23c, -375, and -4328

    Author : Helena Järemo; Pernilla Wikström; Maria Brattsand; Anders Bergh; Elin Thysell; Guido Jenster; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer bone metastases; microRNA; metastatic subtypes; extracellular vesicles; Pathology; patologi;

    Abstract : Non-coding microRNAs (miRNAs) function as post-transcriptional regulators of gene expression by interacting with messenger RNA. Dysregulation of miRNAs has many possible consequences, including tumor-suppressive or -promoting ones, and restoring or preventing the effects of miRNA alteration has therapeutic potential. READ MORE

  4. 2. Transcriptional Regulation by Hypoxia-Inducible Factors in Tumor Cells

    Author : Tobias Löfstedt; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancerology; oncology; Biomedicinska vetenskaper; Medicine human and vertebrates ; Medicin människa och djur ; Cytology; Biomedical sciences; MXI1; ID2; differentiation; HIF; hypoxia; transcription; cancer; neuroblastoma; Cytologi; onkologi;

    Abstract : Cancer is a major cause of human morbidity and mortality, and the risk of developing cancer is about one in three life times. Neuroblastoma is the most common extra-cranial solid tumor among children and arises from early sympathetic nervous system (SNS) cells arrested in their development. READ MORE

  5. 3. Translational studies of metastatic melanoma in the era of immunotherapy - from humanized mouse models to clinical trials

    Author : Henrik Jespersen; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Metastatic melanoma; Uveal melanoma; Humanized mouse models; Immunotherapy; Chimeric antigen receptor T cells; PD-1 inhibition; Epigenetics; Histone deacetylase inhibition;

    Abstract : Immunotherapy with PD-1 inhibitors has transformed the treatment of met-astatic cutaneous mela- noma, and can lead to complete and durable responses in a proportion of patients. However, in around half of the patients, the treatment has little or no effect. READ MORE

  6. 4. Investigating ALK inhibitors alone or in combination as therapeutic options for ALK-positive neuroblastoma

    Author : Muhammad Wasi Alam; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroblastoma; Oncology; Anaplastic lymphoma kinase ALK ; Dihydroorotate Dehydrogenase DHODH ;

    Abstract : Neuroblastoma (NBL) is the third most common pediatric cancer after leukemia and cranial tumours and accounts for around 15% of death in pediatric malignancy. NBL develops due to the poorly differentiated progenitor cells of the sympathetic nervous system. READ MORE

  7. 5. Using genetics to identify epigenetic and signal transduction targets in cancer

    Author : Joydeep Bhadury; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; BETi; HDACi; ATRi; miRNA; NGS; PDX; CDX;

    Abstract : Cancer arises mostly due to the stepwise acquisition of untamed growth capabilities by various means, ranging from genetic, epigenetic to environmental factors. With the advancement made in molecular biology and associated fields, the complex biological circuits leading to these pathological conditions have now started to be deciphered in-depth. READ MORE