Search for dissertations about: "genetic risk score"

Showing result 1 - 5 of 67 swedish dissertations containing the words genetic risk score.

  1. 1. Genetic Determinants of Dyslipidemia

    University dissertation from Lund University, Faculty of Medicine

    Author : Tibor V Varga; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetic epidemiology; Genetic polymorphism; dyslipidaemia; Cholesterol; Triglyceride; Genetic risk; genetic risk score; Single nucleotide polymorphism; Prediction; Gene-environment interactions; Randomized controlled trial; prospective cohort studies; Observational study; GLACIER Study; Diabetes Prevention Program;

    Abstract : Dyslipidemia is a chronic deviation from normal blood lipid levels that can lead to atherosclerosis and other cardiovascular diseases; dyslipidemia and its sequelae are caused by the complex interplay of genetic and environmental factors. Although circulating concentrations of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (LDL-C) have a strong genetic underpinning, not much is known about the genetic factors that affect long-term deteriorations in lipid concentrations. READ MORE

  2. 2. Genetic and Environmental Factors in Cardiometabolic Risk

    University dissertation from Lund University, Faculty of Medicine

    Author : Yan Chen; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Abstract: Cardiovascular diseases and diabetes mellitus are closely linked by sharing common risk factors, such as obesity, insulin resistance, hypertension and dyslipidaemia. These intermediate risk factors are affected by the joint effects of environment and genetics. READ MORE

  3. 3. Genetic and Environmental Risk Factors in the Development of Obesity

    University dissertation from Genetic and Molecular Epidemiology

    Author : Shafqat Ahmad; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; [2015]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Lifestyle behaviors and genetic variation have clear and distinguishable effects on obesity risk; however, the pattern of disease occurrence within and between populations that differ in their genetic and environmental underpinnings suggests obesity is caused in part by the interaction between adverse lifestyle behaviors and the genetic risk profile of an individual. This thesis aims to investigate the joint effects of genetic and environmental (specifically lifestyle) risk factors for obesity and its comorbidities using cross-sectional and longitudinal epidemiological cohorts and clinical trials. READ MORE

  4. 4. Genetic Determinants of Obesity in Relation to Diet, Weight Gain and Mortality

    University dissertation from Department of Clinical Sciences, Lund University

    Author : Gull Rukh; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; genetic variants; copy number variants; genetic risk score; BMI; gene-diet interactions; annual weight change; substantial weight gain; sugar-sweetened beverages; mortality; Mendelian randomization;

    Abstract : Popular Abstract in Swedish Fetma är ett världsomfattande hälsoproblem som drabbar rika och fattiga länder i samma utsträckning och leder till minskad förväntad livslängd. Detta är inte bara ett problem i sig utan för med sig ytterligare följdsjukdomar så som diabetes, hjärt- kärlsjukdomar, vissa former av cancer och artros. READ MORE

  5. 5. Interaction between dietary factors and genetic risk for lipoprotein traits and cardiovascular disease

    University dissertation from Department of Clinical Sciences, Lund University

    Author : Sophie Hellstrand; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; [2015]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diet; polyunsaturated fatty acids; diet quality index; fatty acid desaturase; blood lipids; lipoproteins; polymorphisms; genetic risk score; gene-diet interaction; cohort; epidemiology; cardiovascular disease;

    Abstract : Popular Abstract in Swedish Sambanden mellan kostens sammansättning och risk för hjärt-kärlsjukdom är i många fall oklara. En kost rik på fleromättade fettsyror har ansetts kunna ge skydd mot hjärt-kärlsjukdom, men resultaten från olika studier är motstridiga. READ MORE