Search for dissertations about: "genetic risk score"

Showing result 11 - 15 of 96 swedish dissertations containing the words genetic risk score.

  2. 11. Genetic Contributions to Manifestations and Prognosis of Systemic Lupus Erythematosus

    Author : Sarah Reid; Dag Leonard; Timothy Niewold; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Systemic lupus erythematosus; genetics; cardiovascular disease; polygenic risk score; smoking; Medicinsk vetenskap; Medical Science;

    Abstract : Systemic lupus erythematosus (SLE) is a severe autoimmune disease with a multifactorial aetiology and an extremely heterogenous clinical picture. This thesis explores the impact of SLE genetic variants, through their cumulative effect or gene-environment interactions, on SLE manifestations and complications. READ MORE

  4. 12. Genetic and Environmental Risk Factors in the Development of Obesity

    Author : Shafqat Ahmad; Genetisk och molekylär epidemiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Lifestyle behaviors and genetic variation have clear and distinguishable effects on obesity risk; however, the pattern of disease occurrence within and between populations that differ in their genetic and environmental underpinnings suggests obesity is caused in part by the interaction between adverse lifestyle behaviors and the genetic risk profile of an individual. This thesis aims to investigate the joint effects of genetic and environmental (specifically lifestyle) risk factors for obesity and its comorbidities using cross-sectional and longitudinal epidemiological cohorts and clinical trials. READ MORE

  5. 13. Genetic epidemiology of prostate cancer

    Author : Fredrik Wiklund; Henrik Grönberg; Douglas Easton; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; prostate cancer; epidemiology; genetics; linkage analysis; genome-wide scan; Onkologi; Oncology; Onkologi; Oncology; onkologi;

    Abstract : Prostate cancer is a major health burden throughout the world, yet the etiology of prostate cancer is poorly understood. Evidence has accumulated supporting the existence of a hereditary form of this disease. READ MORE

  6. 14. The role of genetics in regulation of weight loss and food intake

    Author : Marcus Bandstein; Helgi Schiöth; Jarl Torgerson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; FTO; RYGB; LYPLAL1; TFEQ; Genetic Risk Score; methylation; food intake; Bioinformatics; Bioinformatik; Medicinsk genetik; Medical Genetics;

    Abstract : While obesity is a world leading health problem, the most efficient treatment option for severely obese patients is Roux-Y gastric bypass (RYGB) surgery. However, there are large inter-individual differences in weight loss after RYGB surgery. READ MORE

  7. 15. Genetic studies of colorectal cancer

    Author : Johanna Skoglund; Karolinska Institutet; Karolinska Institutet; []
    Keywords : colorectal cancer; linkage analysis; TGFBR1; case-control study; meta-analysis;

    Abstract : Colorectal cancer is the third most commonly diagnosed cancer worldwide with an incidence rate of over 1 million cases per year. A genetic contribution has been suggested to be involved in around 35% of all colorectal cancer cases. READ MORE