Search for dissertations about: "genetic risk score"

Showing result 21 - 25 of 96 swedish dissertations containing the words genetic risk score.

  2. 21. Genetic factors affecting pregnancy duration in humans

    Author : Jonas Bacelis; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; genomics; GWAS; Mendelian randomization; causal inference; preterm birth; pregnancy; gestation; height; text mining;

    Abstract : This thesis investigates the mechanisms behind human pregnancy duration. Too short gestation is a direct cause of perinatal, neonatal, and infant mortality. Deviation from normal pregnancy length is also associated with a child's morbidity, even in the adulthood. READ MORE

  4. 22. Diabetes, Cognitive Ability and Dementia - Epidemiological, Metabolic and Genetic Aspects

    Author : Elin Dybjer; Internmedicin - epidemiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cognitive ability; dementia; diabetes; epidemiology; polygenic risk score; Mendelian randomization;

    Abstract : .... READ MORE

  5. 23. Cardiovascular risk factors, brain structure, and cognitive decline in old age : a population-based study

    Author : Rui Wang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Cardiovascular risk factors;

    Abstract : This doctoral thesis investigated the burden of cardiovascular risk factors among older adults (age ≥60 years) living in central Stockholm (Study I) and the associations of these risk factors with structural brain characteristics and cognitive decline in aging, taking genetic background (APOE gene) into account (Studies II, III, and IV). All studies in this thesis use data from the Swedish National study on Aging and Care in Kungsholmen (SNAC-K) and the embedded SNAC-K Magnetic Resonance Imaging (MRI) study. READ MORE

  6. 24. Genetics of Diabetes Subtypes. Characterization of novel cluster-based diabetes subtypes

    Author : Dina Mansour Aly; diabetes och endokrinologi Genomik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Precision medicine; Diabetes Subclassification; genome-wide association studies; GWAS; genetic risk scores; GRS; chronic kidney disease; CKD; diabetic kidney disease; DKD; Estimated glomerular filtration rate; eGFR; ANDIS; diabetes; diabetics;

    Abstract : BACKGROUND: Type 2 diabetes (T2D) has been reproducibly clustered into five subtypes based on six-clinical variables; age at diabetes onset, body mass index (BMI), Glutamic acid decarboxylase autoantibodies (GADA), glycated hemoglobin (HbA1c) and insulin secretion and resistance estimated as HOMA2B and HOMA2IR derived from fasting glucose and Cpeptide. These subtypes have different disease progression and risk of complications. READ MORE

  7. 25. Cardiovascular Risk Genes in Prevention and Treatment Response

    Author : Viktor Hamrefors; Kardiovaskulär forskning - hypertoni; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; blood pressure treatment; hypertension; statins; dyslipidemia; cardiovascular prevention; cardiovascular genetics; stroke; coronary artery disease; chromosome 9p21; pharmacogenetics; pharmacogenomics;

    Abstract : GENERAL AIM: To investigate how common single-nucleotide-polymorphisms (SNPs) that associate with cardiovascular disease (CVD) could be used in prevention and treatment of CVD. SUBJECTS: Subjects from the population-based Malmö-Diet-and-Cancer-(MDC)-Study (n=30447) and hypertensives from the Nordic-Diltiazem-(NORDIL)-Study (n=10881). READ MORE