Search for dissertations about: "genetic tools"

Showing result 1 - 5 of 310 swedish dissertations containing the words genetic tools.

  2. 1. Advances in studying the role of genetic divergence and recombination in adaptation in non-model species

    Author : Ramprasad Neethiraj; Christopher Wheat; Sören Nylin; Mathieu Joron; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Recombination; Genetic divergence; Lepidoptera; Genetic variation; Genetic diversity; Holocentric chromosomes; cis-regulatory variation; Allele-specific expression; populationsgenetik; Population Genetics;

    Abstract : Understanding the role of genetic divergence and recombination in adaptation is crucial to understanding the evolutionary potential of species since they can directly affect the levels of genetic variation present within populations or species. Genetic variation in the functional parts of the genome such as exons or regulatory regions is the raw material for evolution, because natural selection can only operate on phenotypic variation already present in the population. READ MORE

  4. 2. Next generation tools for microbial cell factories

    Author : Alister James Cumming; Daniel Daley; Neil Dixon; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Microbial cell factories; Recombinant protein production; Bacteria; Plasmid; Genetic sensor; Inducible promoter; Genetic cassette; biokemi; Biochemistry;

    Abstract : The bacterium E. coli is a popular choice for expressing recombinant proteins. It is easy to culture and many molecular tools for are available for directing protein production. When producing recombinant proteins, high yields and good quality soluble products are desirable. READ MORE

  5. 3. Computational discovery of DNA methylation patterns as biomarkers of ageing, cancer, and mental disorders : Algorithms and Tools

    Author : Behrooz Torabi Moghadam; Jan Komorowski; Manfred Grabherr; Jaak Vilo; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; DNA methylation; machine learning; biomarker; cancer; ageing; classification;

    Abstract : Epigenetics refers to the mitotically heritable modifications in gene expression without a change in the genetic code. A combination of molecular, chemical and environmental factors constituting the epigenome is involved, together with the genome, in setting up the unique functionality of each cell type. READ MORE

  6. 4. Genetic Studies of Rheumatoid Arthritis using Animal Models

    Author : Niklas Nordquist; William Dietrich; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Complex disease; autoimmune; rheumatoid arthritis; genetic; mapping; QTL; locus; linkage; animal model; rat; Genetik; Clinical genetics; Klinisk genetik; Medical Genetics; medicinsk genetik;

    Abstract : Predisposition to autoimmune diseases such as, rheumatoid arthritis, diabetes, and multiple sclerosis, is caused by the effect of multiple genes and a strong influence from the environment. In this study, I have investigated genetic factors that confer susceptibility to rheumatoid arthritis in a rat model. READ MORE

  7. 5. Tools and pipelines for interpreting the impacts of genetic variants

    Author : Abhishek Niroula; Proteinbioinformatik; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Bioinformatics; Genetic variants; Machine Learning; cancer genomics; Variation interpretation;

    Abstract : Next generation sequencing (NGS) methods have been widely used for diagnosis. As time and cost of sequencing has reduced sharply during the last decade, genome and exome-wide sequencing have increasingly been used. READ MORE