Search for dissertations about: "genetic variability chronic"

Showing result 1 - 5 of 23 swedish dissertations containing the words genetic variability chronic.

2. 1. Genetic variability of hepatitis B virus in chronic infection

   Author : Charles Hannoun; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hepatitis B virus; mutation; genotype; phylogeny; ; Recombination; coinfection; interferon; response;

   Abstract : Chronic hepatitis B is a major health problem, and may lead to cirrhosis and hepatocellular carcinoma. The liver damage in hepatitis B virus (HBV) infection is considered to be a result of the immune response, and not a cytopathic effect of the virus itself. READ MORE

4. 2. Transcriptional patterns in inflammatory disease

   Author : Johan Lindberg; Joakim Lundeberg; Eivind Hovig; KTH; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Gene expression profiling; transcription; microarray; rheumatoid arthritis; synovial tissue; variability; TNF‐α; anti‐TNF treatment; periodontitis; PGE2; Bioengineering; Bioteknik;

   Abstract : In the studies this thesis is based upon, microarrays were applied to profilemRNA populations in biological samples to gain insights into transcriptionalpatterns and their relation to inflammatory disease.Rheumatoid arthritis (RA) is a chronic inflammatory disease, which leads todegradation of cartilage and bone. READ MORE

5. 3. Geographic and genetic diversity of hepatitis B

   Author : Erik Alestig; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hepatitis B virus; genotype; phylogeny; molecular epidemiology; sequence analysis; mutation;

   Abstract : Hepatitis B Virus (HBV) infection is a global health problem and may lead to chronic hepatitis, liver cirrhosis and hepatocellular cancer. The ability of HBV to adapt to the host environment by genetic variation has lead to the evolution of 8 established (A-H) and 2 putative genotypes (I-J), each corresponding to a rather well-defined geographical distribution. READ MORE

6. 4. Immune modulation in chronic HBV and HCV infection

   Author : Catharina Hultgren; Karolinska Institutet; Karolinska Institutet; []
   Keywords : HBV; HBeAg; HCV; NS3; chronic infection; humoral cellular immune response; Th1 Th2 cells; proliferative response;

   Abstract : Chronic viral hepatitis is a major health problem worldwide. The two major viral causes for chronic hepatitis are the hepatitis B (HBV) and C viruses (HCV). HBV is a DNA virus with a rather limited genetic variability whereas HCV is an RNA virus with a high genetic variability. READ MORE

7. 5. Gene expression and genetic association studies in eczema

   Author : Agne Liedén; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Eczema is an itching relapsing and often chronic inflammatory skin disorder associated with cutaneous hyper reactivity to environmental triggers that are innocuous to normal individuals. The differentiation of epidermal keratinocytes leads to the formation of a physical barrier and together with appropriate innate immune responses produce a functional epidermal barrier protecting us against a number of detrimental factors in the external environment. READ MORE