Search for dissertations about: "genetic variant"

Showing result 16 - 20 of 332 swedish dissertations containing the words genetic variant.

  2. 16. Genetic studies of depressive symptoms

    Author : Mårten Jansson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Depressive Symptoms; Twin; Heritability; Serotonin receptor 2A; Serotonin transporter; MAOA; MAOB; Thrombocyte MAO activity; Linkage Disequilibrium.;

    Abstract : This thesis is focused on depressive symptoms particularly in late fife. Depressive symptoms are associated with serious negative outcomes a greater level of disability and with excess morbidity and mortality. READ MORE

  4. 17. Genetic association studies in stroke

    Author : Claes Ladenvall; Göteborgs universitet; []
    Keywords : stroke; ischemic stroke subtypes; subarachnoid hemorrhage; genetics; polymorphism; fibrinolysis; tPA; PAI-1; TAFI; CRP; Factor XIII;

    Abstract : Stroke is the third most common cause of death and the most common cause of disability in adults in developed countries. It is a complex disease in which genetic and environmental factors make about equal contributions. READ MORE

  5. 18. Genetic studies in rheumatoid arthritis : familial studies and analysis of relationships to atherothrombotic comorbidity

    Author : Lisbeth Ärlestig; Solbritt Rantapää Dahlqvist; Dan Holmberg; Åsa Torinsson Naluai; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rheumatoid arthritis; genetics; familial studies; ACPA and cardiovascular co-morbidity; reumatologi; rheumatology; genetik; Genetics; cardiovascular disease; hjärt- och kärlforskning;

    Abstract : Background. Rheumatoid arthritis (RA) is an autoimmune disease mainly affecting the joints but has also extra articular manifestations and an increased cardiovascular (CV) co-morbidity. Rheumatoid factor (RF) and antibodies against citrullinated proteins/peptides (ACPA) are diagnostically important and are related to a more severe disease. READ MORE

  6. 19. Genetic variants for liver fat accumulation and circulating triglyceride levels

    Author : Ivana Stojkovic; Diabetes - kardiovaskulär sjukdom; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NAFLD; genetic variations; triglycerides; ALAT; dietary intake; type 2 diabetes; cardiovascular disease;

    Abstract : Non-alcoholic fatty liver disease (NAFLD), obesity and type 2 diabetes(T2D) are strongly associated and today their prevalence reaches epidemic proportions. NAFLD has a multi-factorial aetiology, both genetic and environmental factors are equally important. READ MORE

  7. 20. Hunting a Silent Killer. Biomolecular Approaches in Ovarian Cancer

    Author : Nicolai Arildsen; Bröstcancer-genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ovarian cancer; Molecular biology; genetic variant; TP53 mutation; early detection; Drug Screening Assays; Antitumor; bioinformatics; next generation sequencing; NGS; prognostic and predictive biomarkers; ovarian clear cell cancer; high-grade serous ovarian cancer;

    Abstract : Ovarian cancer is a heterogeneous disease and recent advances in improving patient outcome havebeen limited. It is estimated that a woman’s risk of developing ovarian cancer during her lifetime is about 1 in 70, making it a frequently occurring cancer type in women. READ MORE