Search for dissertations about: "genome instability"

Showing result 1 - 5 of 49 swedish dissertations containing the words genome instability.

  2. 1. Genome instability, gene expression and prognosis in breast cancer

    Author : Ulrike Kronenwett; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Breast adenocarcinoma; genomic instability; SSI; centrosomes;

    Abstract : Aneuploid cancers are regarded as being more malignant than tumors of other ploidy categories, and they are characterized by increased genomic instability. Our investigations resulted in the characterization of an aneuploid subtype of breast carcinoma that proved to be genomically stable. READ MORE

  4. 2. Genome dynamics and virulence in the human pathogen Candida glabrata

    Author : Khadija Mohamed Ahmad; Molekylär cellbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Pathogenic yeast; Candida glabrata; small chromosomes; Genome rearrangement; Haploid and diploid yeast; RNA interference.;

    Abstract : Although the yeast Candida glabrata is considered to be a part of the commensal microflora in healthy individuals, during the last years it has been frequently isolated from patients with mucosal and systemic fungal infections. Now it is considered as the second most frequently isolated pathogenic yeast after Candida albicans. Despite its name, C. READ MORE

  5. 3. Genotoxic effects of systemic chemotherapy in cancer patients, with special focus on the relation between MSI, LOH and development of secondary cancers

    Author : Nasir K. Kamat; Ulf Rannug; Giovanni Corso; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chemotherapy; Genetic instability; Microsatellites instability; Loss of heterozygosity; Mismatch repair; molekylärgenetik; Molecular Genetics;

    Abstract : Systemic chemotherapy results in both phenotypic and genotypic side effects. Genotoxicity posed by chemotherapy is a major concern since it induces DNA damage and instability in the patients’ genome. READ MORE

  6. 4. Ribonucleotides in DNA - Application in genome-wide DNA polymerase tracking and physiological role in eukaryotes

    Author : Katrin Kreisel; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ribonucleotides; DNA instability; DNA polymerase eta; nuclear DNA; mitochondrial DNA;

    Abstract : The genetic code in the eukaryotic cell is stored in the form of DNA, which is more resistant to hydrolysis than RNA. Replication fidelity and DNA repair mechanisms are in place to ensure genomic integrity to preserve the information encoded. READ MORE

  7. 5. The mitotic instability of human minisatellites integrated into the genome of Saccharomyces cerevisiae

    Author : Shohreh Maleki; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : .... READ MORE