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Showing result 1 - 5 of 113 swedish dissertations matching the above criteria.

  2. 1. Guardians of the genome : Connecting chromatin structure and genome integrity in Saccharomyces cerevisiae

    Author : Stefanie Lena Bauer; Stefan U. Åström; Brian Luke; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; molekylär biovetenskap; Molecular Bioscience;

    Abstract : Branched DNA structures arise during recombination and during other DNA repair processes such as repair of stalled replication forks. One branched structure, the Holliday Junction (HJ), is a four-way junction that can connect sister chromatids or homologous chromosomes. We show a physical interaction between the HJ-cleaving enzyme Yen1 and Uls1. READ MORE

  4. 2. Chromosome-specific adaptations of RNA stability and the roles of the roX RNAs in dosage compensation

    Author : Marie-Line Faucillion; Jan Larsson; Jean-Yves Roignant; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Drosophila melanogaster; dosage compensation; buffering; RNA stability; RNA decay; RNA half-life; RNA-seq; genome-wide; sex chromosomes; evolution; roX1; roX2; POF; MSL; molekylärbiologi; Molecular Biology;

    Abstract : Sex chromosomes evolved from an ancient pair of autosomes and the Y chromosome lost most of its genetic information in the process. This created two kinds of genomic imbalances: the first one between males (XY) and females (XX) and the second one between the sex chromosomes and the autosomes (X:AA). READ MORE

  5. 3. Systems-level characterization of probiotic bifidobacteria - Towards rational optimization of industrial production

    Author : Marie Schöpping; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; genome-scale metabolic modeling; stability; robustness; industrial manufacturing; bifidobacteria; stress-associated genes; probiotics; nutritional requirement; interspecies variations;

    Abstract : Probiotic Bifidobacterium strains contribute to a healthy gut microbiota of their hosts. Increasing public awareness of this positive effect has resulted in a growing demand for these microorganisms. READ MORE

  6. 4. The Smc5/6 complex : the mysterious guardian of genome stability

    Author : Davide G Berta; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : An intricate network of proteins ensures the faithful transmission of genetic information through cell generations. The Structural Maintenance of Chromosomes (SMC) protein complex family plays a pivotal role in maintaining genome stability. READ MORE

  7. 5. Regulation of ribonucleotide reductase and the role of dNTP pools in genomic stability in yeast Saccharomyces cerevisiae

    Author : Olga Tsaponina; Andrei Chabes; Ola Hammarsten; Umeå universitet; []
    Keywords : ribonucleotide reductase; dNTP; genome stability;

    Abstract : Every living organism is programmed to reproduce and to pass genetic information to descendants. The information has to be carefully copied and accurately transferred to the next generation.  Therefore organisms have developed the network of conserved mechanisms to survey the protection and precise transfer of the genetic information. READ MORE