Search for dissertations about: "genome-scale metabolic model"

Showing result 1 - 5 of 20 swedish dissertations containing the words genome-scale metabolic model.

  2. 1. On metabolic networks and multi-omics integration

    Author : Rasmus Ågren; Chalmers University of Technology; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; succinate; genome-scale metabolic model; metabolic engineering; systems biology; penicillin; NASH; flux balance analysis; metabolism; cancer; reconstruction;

    Abstract : Cellular metabolism is a highly complex chemical system, involving thousands of interacting metabolites and reactions. The traditional approach to understanding metabolism has been that of reductionism; by isolating and carefully measuring the involved components, the goal has been to understand the whole as the sum of its parts. READ MORE

  4. 2. Utilization of single-cell RNA-Seq and genome-scale modeling for investigating cancer metabolism

    Author : Johan Gustafsson; Chalmers University of Technology; []
    Keywords : NATURVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; MEDICAL AND HEALTH SCIENCES; single-cell RNA-Seq; cancer; metabolism; genome-scale metabolic modeling;

    Abstract : Cancer remains a leading cause of death worldwide, and its dysregulated metabolism is a promising target for therapy. However, metabolism is complex to study – the metabolism of a cell involves the interplay of thousands of chemical reactions that are combined in different ways across tissues and cell types. READ MORE

  5. 3. Modeling human gut microbiota: from steady states to dynamic systems

    Author : Hao Luo; Chalmers University of Technology; []
    Keywords : NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; NATURAL SCIENCES; genome-scale metabolic model; cybernetic model; gut microbiota; metabolic modeling; dynamics.;

    Abstract : Human gut microbes are an essential part of human sub-microscopic systems and involved in many critical biological processes such as Type 2 diabetes (T2D) and osteoporosis. However, the underlying mechanisms are unclear. READ MORE

  6. 4. Improving cyanobacteria productivity: From theory to assay

    Author : Kiyan Shabestary; Elton P. Hudson; Daniel Ducat; KTH; []
    Keywords : ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; metabolic engineering; growth-coupling; growth-arrest; cyanobacteria; CRISPRi; CRISPRi library; flux balance analysis; genome-scale model; butanol; lactate; isoprene; Bioteknologi; Biotechnology;

    Abstract : Bio-based production of biochemicals and biofuels holds great promises for the transition towards a more sustainable society. With increasing levels of carbon dioxide (CO2) in the atmosphere, cyanobacteria stand apart as natural catalysts directly converting CO2 and light to product. READ MORE

  7. 5. Metabolic Modeling of the Gut Microbiome-Host Interactions and Meta’omics Integration

    Author : Saeed Shoaie; Chalmers University of Technology; []
    Keywords : NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; NATURAL SCIENCES; meta’omics; complexity; obesity; network topology; Gut microbiome; genome-scale metabolic model; gene richness; CASINO; systems biology; flux balance analysis; diabetes;

    Abstract : A large number of microbes with different strain types occupy the human gut. These gut inhabitant microbes have key roles in decomposition of indigestible dietary macronutrients before they are metabolised by the host. READ MORE