Search for dissertations about: "genome-scale metabolic models"
Showing result 1 - 5 of 19 swedish dissertations containing the words genome-scale metabolic models.
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1. Utilization of single-cell RNA-Seq and genome-scale modeling for investigating cancer metabolism
Abstract : Cancer remains a leading cause of death worldwide, and its dysregulated metabolism is a promising target for therapy. However, metabolism is complex to study – the metabolism of a cell involves the interplay of thousands of chemical reactions that are combined in different ways across tissues and cell types. READ MORE
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2. On metabolic networks and multi-omics integration
Abstract : Cellular metabolism is a highly complex chemical system, involving thousands of interacting metabolites and reactions. The traditional approach to understanding metabolism has been that of reductionism; by isolating and carefully measuring the involved components, the goal has been to understand the whole as the sum of its parts. READ MORE
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3. A systems biology understanding of protein constraints in the metabolism of budding yeasts
Abstract : Fermentation technologies, such as bread making and production of alcoholic beverages, have been crucial for development of humanity throughout history. Saccharomyces cerevisiae provides a natural platform for this, due to its capability to transform sugars into ethanol. READ MORE
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4. Modeling human gut microbiota: from steady states to dynamic systems
Abstract : Human gut microbes are an essential part of human sub-microscopic systems and involved in many critical biological processes such as Type 2 diabetes (T2D) and osteoporosis. However, the underlying mechanisms are unclear. READ MORE
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5. Metabolic Modeling of the Gut Microbiome-Host Interactions and Meta’omics Integration
Abstract : A large number of microbes with different strain types occupy the human gut. These gut inhabitant microbes have key roles in decomposition of indigestible dietary macronutrients before they are metabolised by the host. READ MORE