Search for dissertations about: "genome-scale modeling"

Showing result 1 - 5 of 17 swedish dissertations containing the words genome-scale modeling.

  1. 1. Utilization of single-cell RNA-Seq and genome-scale modeling for investigating cancer metabolism

    Author : Johan Gustafsson; Chalmers University of Technology; []
    Keywords : NATURVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; MEDICAL AND HEALTH SCIENCES; single-cell RNA-Seq; cancer; metabolism; genome-scale metabolic modeling;

    Abstract : Cancer remains a leading cause of death worldwide, and its dysregulated metabolism is a promising target for therapy. However, metabolism is complex to study – the metabolism of a cell involves the interplay of thousands of chemical reactions that are combined in different ways across tissues and cell types. READ MORE

  2. 2. Systems Biology of Protein Secretion in Human Cells: Multi-omics Analysis and Modeling of the Protein Secretion Process in Human Cells and its Application

    Author : Rasool Saghaleyni; Chalmers University of Technology; []
    Keywords : Erythropoietin; cancer protein secretory pathway; protein secretion modeling; HEK293; protein secretion; Integrative omics analysis; genome-scale modeling;

    Abstract : Since the emergence of modern biotechnology, the production of recombinant pharmaceutical proteins has been an expanding field with high demand from industry. Pharmaceutical proteins have constituted the majority of top-selling drugs in the pharma industry during recent years. READ MORE

  3. 3. Modeling human gut microbiota: from steady states to dynamic systems

    Author : Hao Luo; Chalmers University of Technology; []
    Keywords : NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; NATURAL SCIENCES; genome-scale metabolic model; cybernetic model; gut microbiota; metabolic modeling; dynamics.;

    Abstract : Human gut microbes are an essential part of human sub-microscopic systems and involved in many critical biological processes such as Type 2 diabetes (T2D) and osteoporosis. However, the underlying mechanisms are unclear. READ MORE

  4. 4. Systems biology of protein synthesis and secretion in yeast

    Author : Qi Qi; Chalmers University of Technology; []
    Keywords : NATURVETENSKAP; TEKNIK OCH TEKNOLOGIER; NATURAL SCIENCES; ENGINEERING AND TECHNOLOGY; multi-omics analysis; protein synthesis; recombinant protein production; genome-scale modeling; protein secretion;

    Abstract : Protein synthesis and secretion is a vital process to maintain cell function. As it demands numerous building blocks, cofactors and chaperones generated from metabolism and translation, the process is intertwined with metabolic and regulatory networks. READ MORE

  5. 5. Computing abundance constraints in Saccharomyces cerevisiae’s metabolism

    Author : Benjamín José Sánchez; Chalmers University of Technology; []
    Keywords : NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; NATURAL SCIENCES; Genome-scale modeling; lipidomics; proteomics; flux balance analysis;

    Abstract : The unicellular eukaryotic organism Saccharomyces cerevisiae (budding yeast) is routinely used for production of high-value chemical compounds in the biotechnology industry. To improve production yields, it is fundamental to understand cellular metabolism, i.e. all biochemical reactions that occur inside the cell. READ MORE