Search for dissertations about: "genome-scale modeling"

Showing result 6 - 10 of 19 swedish dissertations containing the words genome-scale modeling.

  2. 6. Computing abundance constraints in Saccharomyces cerevisiae’s metabolism

    Author : Benjamín José Sánchez; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Genome-scale modeling; lipidomics; proteomics; flux balance analysis;

    Abstract : The unicellular eukaryotic organism Saccharomyces cerevisiae (budding yeast) is routinely used for production of high-value chemical compounds in the biotechnology industry. To improve production yields, it is fundamental to understand cellular metabolism, i.e. all biochemical reactions that occur inside the cell. READ MORE

  4. 7. Engineering yeast for improved recombinant protein production

    Author : Yanyan Wang; Chalmers tekniska högskola; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; point mutation; genome-scale modeling; recombinant protein; omics analysis; CRISPR Cas9; protein secretion; Saccharomyces cerevisiae;

    Abstract : Recombinant proteins are broadly used from basic research to therapeutic development and include industrial enzymes and pharmaceutical proteins. The increasing demand for improved production and enhanced quality of recombinant proteins requires robust biotech-based strategies to overcome the limitations of protein extraction from natural sources. READ MORE

  5. 8. Systems Analysis of the Protein Secretory Pathway in Yeast and Human Cells

    Author : Amir Feizi; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; protein production; flux balance analysis; biopharmaceutical; secretory pathway: secretome; recombinant protein; genome-scale modeling; systems biology;

    Abstract : The cell was discovered by Robert Hooke in 1665, later in nineteen century the cell theory was developed as all organisms are composed of one or more cells. Since then, many tools and experimental methods have been developed to dissect and characterize the cell components which resulted in established solid scientific fields such as biochemistry, molecular cell biology and genetics. READ MORE

  6. 9. Constraint-based modeling of yeast metabolism and protein secretion

    Author : Feiran Li; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; protein secretion; metabolism; yeast evolution; genome-scale metabolic model; phenotype diversity;

    Abstract : Yeasts are extensively exploited as cell factories for producing alcoholic beverages, biofuels, bio-pharmaceutical proteins, and other value-added chemicals. To improve the performance of yeast cell factories, it is necessary to understand their metabolism. READ MORE

  7. 10. Heterogeneity of human metabolism in health and disease: a modelling perspective

    Author : Pouyan Ghaffari Nouran; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer metabolism; fatty acid metabolism; genome-scale metabolic models; community modeling; heterogeneity; lung cancer; amino acids metabolism; gut microbiome;

    Abstract : Metabolism is broadly defined as the sum of biochemical reactions within cells that are involved in maintaining the living state of the organism. Profound importance of metabolism comes from the fact that it is the sole source of energy that allows life to resist to be degraded into entropy. READ MORE