Search for dissertations about: "genome-wide scan"

Showing result 11 - 15 of 32 swedish dissertations containing the words genome-wide scan.

  2. 11. The genetic complexity of celiac disease. Gene variants linked and associated to an inflammatory autoimmune disorder

    Author : Åsa Torinsson Naluai; Göteborgs universitet; []
    Keywords : Celiac disease; genome-wide scan; linkage; association; complex disease; autoimmune; CTLA4; 5q31-33; polymorphism;

    Abstract : .... READ MORE

  4. 12. On the genetics of hereditary breast/ovarian cancer. BRCA1, BRCA2 and beyond

    Author : Annika Bergman; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; BRCA1; BRCA2; breast cancer; hereditary cancer; founder mutation; mutation analysis; linkage analysis; genome scan; BRCAX;

    Abstract : Breast cancer is the most common malignancy in women. Most of the breast cancers are sporadic with no apparent inheritance factor but about 5-10% is believed to be caused by an inherited predisposition. Aims: This thesis aimed at defining the BRCA1/2 mutation spectrum of the west Swedish population and specifically to characterize the BRCA1c. READ MORE

  5. 13. The genetics of systemic lupus erythematosus : Mapping of susceptibility loci for human SLE

    Author : Anna-Karin B. Lindqvist; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Systemic lupus erythematosus; complex diseases; genetic susceptibility; linkage analysis; genome scan; candidate gene; Genetik; Clinical genetics; Klinisk genetik; Medical Genetics; medicinsk genetik;

    Abstract : Systemic lupus erythematosus (SLE) is a systemic autoimmune disease affecting organs such as skin, jointsand kidneys. Characteristic for the disease is increased production of autoantibodies, in particular against dsDNA. Previous studies of SLE in mouse models and in humans indicate polygenic inheritance and genetic heterogeneity. READ MORE

  6. 14. Sequence evolution in a chromosomal region of Arabidopsis thaliana

    Author : Jenny Hagenblad; Biologiska institutionen; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Växtgenetik; Plant genetics; flowering time; mapping; polymorphism; Linkage disequilibrium; Arabidopsis thaliana;

    Abstract : Recently there has been a lot of interest in the use of liknage disequilibrium (LD) in genome wide scans for new genes, so called association mapping. Of crucial importance to a genome wide scan for associations between genetic markers and the trait of interest is the extent of LD, as it determines both how closely a trait can be mapped and also how many markers is needed to map it. READ MORE

  7. 15. QTL Analysis in the Pig : From the Identification of Quantitative Trait Loci to the Understanding of Molecular Mechanisms

    Author : Ellen Markljung; Leif Andersson; Göran Andersson; Göran Hjälm; Stefan Marklund; Holger Luthman; Uppsala universitet; []
    Keywords : ;

    Abstract : Domestic pigs have become very different form the wild ancestors they originate from. Selection for muscle growth and meat quality has made the pig a good model for genetic studies of muscle development.The first part of this thesis presents a genome-wide scan for quantitative trait loci (QTL) in a cross between Landrace and Hampshire pigs. READ MORE