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Showing result 1 - 5 of 1778 swedish dissertations matching the above criteria.

  2. 1. Modeling Genome Evolution : Creation, Change and Destruction

    Author : Mats Pettersson; Otto Berg; Paul Sniegowski; Uppsala universitet; []
    Keywords : Molecular biology; Theotretical biology; Population genetics; Stochastic modeling; Genome evolution; Molekylärbiologi;

    Abstract : Historically, evolution has been studied either by looking at morphological traits in living organisms and the fossil record, or by using bioinformatics and comparative genomics. While highly useful for deducing evolutionary history, these approaches are not particularly well suited for studying the mechanisms of evolution. READ MORE

  4. 2. Guardians of the genome : Connecting chromatin structure and genome integrity in Saccharomyces cerevisiae

    Author : Stefanie Lena Bauer; Stefan U. Åström; Brian Luke; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; molekylär biovetenskap; Molecular Bioscience;

    Abstract : Branched DNA structures arise during recombination and during other DNA repair processes such as repair of stalled replication forks. One branched structure, the Holliday Junction (HJ), is a four-way junction that can connect sister chromatids or homologous chromosomes. We show a physical interaction between the HJ-cleaving enzyme Yen1 and Uls1. READ MORE

  5. 3. Studies of Genome Diversity in Bartonella Populations : A journey through cats, mice, men and lice

    Author : Hillevi Lina Lindroos; Siv G. E. Andersson; Richard Birtles; Uppsala universitet; []
    Keywords : Biology; Bartonella; genome content; genome rearrangement; gene expression; phage; microarray; PFGE; MLST; Biologi;

    Abstract : Bacteria of the genus Bartonella inhabit the red blood cells of many mammals, including humans, and are transmitted by blood-sucking arthropod vectors. Different species of Bartonella are associated with different mammalian host species, to which they have adapted and normally do not cause any symptoms. READ MORE

  6. 4. Genome Evolution and Host Adaptation in Bartonella

    Author : Eva Caroline Berglund; Siv GE Andersson; Brendan Wren; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Bartonella; genome evolution; genome diversity; phage; gene transfer agent; secretion system; microarray; Bioinformatics; Bioinformatik; Evolutionary Genetics; evolutionär genetik;

    Abstract : Bacteria of the genus Bartonella infect the red blood cells of a wide range of wild and domestic mammals and are transmitted between hosts by blood-sucking insects. Although most Bartonella infections are asymptomatic, the genus contains several human pathogens. READ MORE

  7. 5. Function and Evolution of Small Regulatory RNAs and their Associated Proteins : A Journey from Genome to Proteome

    Author : Bart Edelbroek; Fredrik Söderbom; Jonathan R. Chubb; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; microRNAs; non-coding RNAs; Evolution; Whole Genome Sequencing; Transcriptomics; Proteomics; small RNAseq; Amoebozoa; Multicellular development; Social amoebae; Comparative genomics; Genome annotation; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology;

    Abstract : Organisms throughout the tree of life have evolved distinct ways to regulate gene expression. Some of these processes involve non-coding RNAs (ncRNAs), which are not translated but functional nonetheless. These ncRNAs are of utmost importance, with dysregulation of some causing severe developmental effects or even being lethal. READ MORE