Search for dissertations about: "genomic organisation"

Showing result 1 - 5 of 10 swedish dissertations containing the words genomic organisation.

  1. 1. Molecular Genetic Studies of the Blood Group ABO Locus in Man

    University dissertation from Blood Centre, University Hospital, S-221 85 Lund, Sweden

    Author : Martin L Olsson; [1997]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chi sequence; recombination; population studies; blood group serology; erythrocyte; blood transfusion; sequencing; DNA; PCR; genomic; Blood group ABO; allele; Immunology; serology; transplantation; Immunologi; serologi; Clinical genetics; Klinisk genetik;

    Abstract : The ABO blood group system is undoubtedly the most important genetic and phenotypic marker in clinical transfusion medicine. The A and B determinants are immunodominant, terminally located carbohydrate residues of glycoconjugates on erythrocytes and other cell surfaces. READ MORE

  2. 2. Monoglyceride Lipase and Hormone-Sensitive Lipase - Molecular and structural aspects

    University dissertation from Department of Cell and Molecular Biology, Lund University

    Author : Marie Karlsson; [2000]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; genomic organisation; baculovirus-insect cells; catalytic triad; alfa beta hydrolase fold; tissue distribution; cDNA sequence; lipolysis; adipocyte; monoglyceride lipase; hormone-sensitive lipase; chromosomal localisation; Clinical biology; Klinisk biologi;

    Abstract : Triglycerides in the adipocyte are hydrolysed by means of three consecutive reactions through the combined action of two lipases: hormone-sensitive lipase (HSL) and monoglyceride lipase (MGL). HSL catalyses the first and rate-limiting step, i.e. READ MORE

  3. 3. Chromosomal Instability and Genomic Amplification in Bone and Soft Tissue Tumours

    University dissertation from Department of Clinical Genetics, Lund University

    Author : David Gisselsson Nord; [2000]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nuclear atypia; kinetochore; anaphase bridge; p53; breakage-fusion-bridge cycle; TP53; HMGIC; MDM2; mitotic instability; genomic instability; FISH; osteosarcoma; liposarcoma; amplification; tumour; chromosome; cytogenetics; Clinical genetics; Klinisk genetik;

    Abstract : Acquired genetic abnormalities are found in all types of malignant tumours and may contribute to neoplastic processes by altering protein structure or dosage. Many bone and soft tissue tumours (BSTT) are characterised by complex patterns of chromosome changes, including extensive intratumour heterogeneity and amplification of DNA sequences. READ MORE

  4. 4. Correlation Between Phenotype and Genotype in Some Clinically Important Blood group Systems

    University dissertation from Department of Transfusion Medicine

    Author : Nidal Irshaid; [2001]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunologi; transplantation; serology; transfusion medicine; Blood group; DNA; Immunology; genomic typing; serologi;

    Abstract : In the past decade, the molecular basis for most of the blood group systems has been investigated intensively. Many blood group genes have been cloned and the polymorphisms of clinically significant blood group systems have been elucidated. READ MORE

  5. 5. The Functional Significance and Chromatin Organisation of the Imprinting Control Regions of the H19 and Kcnq1 Genes

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Meena Kanduri; Rolf Ohlsson; Karl Ekwall; [2004]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular genetics; DNA methylation; Imprinting control region; Chromatin; Insulator; Nucleosome positioning; Genetik; NATURAL SCIENCES Biology Cell and molecular biology Genetics; NATURVETENSKAP Biologi Cell- och molekylärbiologi Genetik;

    Abstract : Genomic imprinting is a phenomenon through which a subset of genes are epigenetically marked during gemtogenisis. This mark is maintained in the soma to often manifest parent of origin-specific monoalleleic expresson patterns. READ MORE