Search for dissertations about: "genotypes"

Showing result 1 - 5 of 415 swedish dissertations containing the word genotypes.

  1. 1. Hepatitis C virus infection. Viral genotypes and factors promoting liver fibrosis

    Author : Johan Westin; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hepatitis C virus; genotypes; epidemiology; liver fibrosis; histology; scoring; prognosis; alcohol; liver steatosis;

    Abstract : Hepatitis C virus (HCV) is associated with chronic infection in a majority of infected individuals. Chronic hepatitis C may result in liver cirrhosis or hepatocellular cancer and is therefore considered a major health problem worldwide. READ MORE

  2. 2. Real-time PCR studies of genotypes, mutations and replication of hepatitis B virus

    Author : Sebastian Malmström; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : hepatitis B virus; real-time PCR; lamivudine resistance; genotypes; replication;

    Abstract : Infection with hepatitis B virus (HBV) is an important cause of liver disease and affects 350 million people worldwide, causing 600,000 deaths/year. Treatment includes interferon and nucleoside analogues (NAs) such as lamivudine, entecavir, and tenofovir. READ MORE

  3. 3. Clinical and genetical aspects of Celiac Disease

    Author : Audur Gudjonsdottir; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; celiac disease; sib-pair; screening; genome-wide scan; linkage analysis; heritability; genotypes; DQ2-negative; phenotypes; autoimmune disease;

    Abstract : Celiac disease (CD), or gluten-sensitive enteropathy, is one of the most common chronic diseases in childhood but is diagnosed in all ages. CD is a genetically driven immunological intolerance to dietary gluten. Th e treatment is a gluten-free diet. READ MORE

  4. 4. Design and Synthesis of Hepatitis C Virus NS3 Protease Inhibitors : Targeting Different Genotypes and Drug-Resistant Variants

    Author : Anna Karin Belfrage; Anja Sandström; Ulf Ellervik; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; hepatitis C virus; HCV; NS3 protease inhibitors; structure-activity relationship; 2 1H -pyrazinone; quinazoline; resistance; Pd catalysis; Medicinal Chemistry; Läkemedelskemi; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : Since the first approved hepatitis C virus (HCV) NS3 protease inhibitors in 2011, numerous direct acting antivirals (DAAs) have reached late stages of clinical trials. Today, several combination therapies, based on different DAAs, with or without the need of pegylated interferon-α injection, are available for chronic HCV infections. READ MORE

  5. 5. Biomolecular characterization of mumps virus genotypes with varying neurovirulence

    Author : Tesfaldet Tecle; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Mumps virus is an RNA virus, which belongs to the Rubula virus genus of the family Paramyxoviridae. Mumps is a common childhood infection. Classically, mumps infection presents as parotitis although it is frequently asymptomatic in young children. READ MORE