Search for dissertations about: "genotypes"

Showing result 21 - 25 of 430 swedish dissertations containing the word genotypes.

  2. 21. Genetic diversity of Plasmodium falciparum infections : influence on protective malaria immunity

    Author : Sándor Bereczky; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Malaria; Plasmodium falciparum; genetic diversity; msp2; IgE; subsequent risk; asymptomatic; DNA extraction; ethnic group; spleen enlargement; hemoglobin;

    Abstract : Detailed knowledge of the interaction between the human host and the antigenic and genetic diversity of Plasmodium falciparum infections is a prerequisite for understanding the mechanisms underlying acquisition of immunity to malaria. This thesis assessed the diversity of P. READ MORE

  4. 22. Functional analysis of the -1087 single nucleotide polymorphism in the IL-10 promoter region

    Author : Lena Larsson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IL-10; B cells; Sp1; transcription factors; gene expression;

    Abstract : Interleukin (IL) 10 is recognized as a pro-inflammatory cytokine that promotes B cell proliferation. The objectives of the present series of studies were to analyze (i) differences in transcription factor binding to the -1087 IL-10 gene polymorphism in B cells, (ii) the influence of the A to G nucleotide transition on IL-10 and Sp1 gene expression in B cells, (iii) differences in Sp1 expression in periodontitis lesions from GG and AA genotype subjects and (iv) epigenetic modifications around the -1087 site and their influence on IL-10 gene expression. READ MORE

  5. 23. Mapping and fine-mapping of genetic factors affecting bovine milk composition

    Author : Sandrine Duchemin; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Abstract : Bovine milk is an important source of nutrients in Western diets. Unraveling the genetic background of bovine milk composition by finding genes associated with milk-fat composition and non-coagulation of milk were the main goals of this thesis. In Chapter 1, a brief description of phenotypes and genotypes used throughout the thesis is given. READ MORE

  6. 24. Significance of polymorphisms in human xenobiotic metabolising enzymes

    Author : Anna-Karin Alexandrie; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cigarette smoke is the primary cause of lung cancer but urban air pollution and certain occupational exposures have also been found to elevate the incidence of lung cancer. These exposures contain polycyclic aromatic hydrocarbons (PAH), which can be metabolically activated to highly reactive compounds capable of binding to DNA and initiating the carcinogenic process unless they are eliminated. READ MORE

  7. 25. The ubiquity and type diversity of papillomaviruses in normal skin

    Author : Annika Antonsson; Malmö Klinisk mikrobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Microbiology; bacteriology; virology; mycology; Mikrobiologi; bakteriologi; virologi; mykologi; skin phylogeny; HPV prevalence; HPV type detrmination; PCR; human papillomavirus; HPV;

    Abstract : Papillomaviruses are a diverse, epitheliotropic group of viruses. Some genotypes are the main cause of anogenital cancer in humans; others can induce skin lesions. In order to investigate the occurrence of subclinical skin infections with human papillomavirus (HPV), a pair of degenerate primers (FAP59/64) was designed. READ MORE