Search for dissertations about: "geranylgeranyl pyrophosphate"

Found 2 swedish dissertations containing the words geranylgeranyl pyrophosphate.

  2. 1. Cardioprotective mechanisms by inhibition of the HMG-CoA reductase pathway and stimulation of peroxisome proliferator-activated receptors in myocardial ischaemia-reperfusion

    Author : Aliaksandr Bulhak; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Endothelial function; endothelin-1; geranylgeranyl pyrophosphate; HMG-CoA reductase; infarct size; ischaemiareperfusion injury; myeloperoxidase; myocardium; nitric oxide; nitric oxide synthase; peroxisome proliferator-activated receptor-alpha; -gamma; PPAR-alpha; -gamma-ligands; RhoA; statins.;

    Abstract : Acute myocardial ischaemia causes metabolic changes and results in a rapid decrease in the energy available to the cell. This leads to cell injury that, depending on the length of the ischaemic time, is reversible or irreversible. READ MORE

  4. 2. Protein modification with hydrophobic prenyl groups in malignant cells

    Author : Magnus Hjertman; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Mevalonate (MVA) is the key intermediate in the isoprene synthetic pathway leading to the formation of a number of biologically important lipid molecules. It is well known that inhibition of MVA synthesis blocks the cell cycle progression of mammalian cells, a fact suggesting that some isoprenoids derived from MVA are required for cell proliferation. READ MORE