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Found 5 swedish dissertations matching the above criteria.

  2. 1. Chosen Children? : An empirical study and a philosophical analysis of moral aspects of pre-implantation genetic diagnosis and germ-line gene therapy

    Author : Kristin Zeiler; Lennart Nordenfelt; Gunilla Tegern; Karin Sporre; Åge Wifstaad; Linköpings universitet; []
    Keywords : HUMANIORA; HUMANITIES; Empirical ethics; pre-implantation genetic diagnosis; germ-line gene therapy; qualitative research; philosophical analysis; medical progress; genetic disease; choice; auautonomous; ambivalence; trust; genetic identity; Genterapi; biologisk etik; medicinsk etik; preimplanatorisk genetisk diagnostik; Philosophy subjects; Filosofiämnen;

    Abstract : With pre-implantation genetic diagnosis (PGD), genetic testing and selective transfer of embryos is possible. In the future, germ-line gene therapy (GLGT) applied to embryos before implantation, in order to introduce missing genes or replace mutant ones, may be possible. READ MORE

  4. 2. B cell repertoire development in normal physiology and autoimmune disease

    Author : Åsa Andersson; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; B cell repertoire; connectivity; natural antibodies; non-obese diabetic NOD ; Ig therapy; Vh7183 gene family;

    Abstract : The B cell repertoire in the neonatal immune system (IS) is characterised by reactivity towards self-components, including other immunoglobulin (Ig) V-regions. These properties have been suggested to be a requirement for the development of a normal immune system. READ MORE

  5. 3. Genetic and epigenetic alterations in melanoma

    Author : Rainer Tuominen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Malignant melanoma is a disease that may arise in several different parts of the body, preferentially the skin, rarely in the mucosal membranes or the choroidal tissues of the eye. The incidence of cutaneous melanoma (CMM) is steadily increasing in the Caucasian populations, unlike uveal melanoma (UM) that shows a stable incidence. READ MORE

  6. 4. Genetic and functional studies on the thyroid hormone axis

    Author : Abdelaziz Elgadi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : This thesis has two main parts. The first is based on the first three papers with a focus on understanding the etiology and pathogenesis of thyroid malfunction and its effects on different organs. READ MORE

  7. 5. Molecular genetics of cutaneous malignant melanoma

    Author : Malihe Eskandarpour; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cutaneous malignant melanoma is an aggressive tumor of melanocytes in the skin with rapidly increasing incidence. Patients with advanced disease have a poor prognosis since the tumor is usually resistant to current therapies. Therefore, the development of novel strategies for preventing and treating melanoma is important. READ MORE