Search for dissertations about: "germinal center GC"

Showing result 1 - 5 of 26 swedish dissertations containing the words germinal center GC.

  2. 1. Regulation of the germinal center response by T follicular helper cells and type I interferons

    Author : Madelene Dahlgren; Adaptivt immunförsvar; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Germinal Center; T follicular helper cell; type I interferon; dendritic cell; adjuvant; differentiation; IgG;

    Abstract : The protective effect of most currently available vaccines is dependent on high-affinity antibodies and long lived B cell memory, which develop within organized structures of secondary lymphoid organs called germinal centers (GCs). GC formation is supported by T follicular helper (Tfh) cells, a subset of CD4+ T cells that develop in parallel to other effector T cells and specifically localizes to B cell follicles. READ MORE

  4. 2. Studies of T- and B-cells for the generation of human antigen specific antibodies

    Author : Eva Andersson; Institutionen för immunteknologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; germinal center; CD4 CD57 T cells; mucin 1; in vitro immunization; human class switched antibodies; Biotechnology; Bioteknik;

    Abstract : Human antibodies generated in vitro may be highly valuable for diagnostic and therapeutic purposes. For a long time most human antibodies produced in vitro have been of the IgM isotype with rather low affinities. In this thesis a method for production of IgG switched antigen-specific human antibodies is presented. READ MORE

  5. 3. Genomic and Molecular Aspects of Mature Human B Cells

    Author : Carl-Magnus Högerkorp; Institutionen för immunteknologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; Human; B-cell; Germinal center; Centroblast; serology; Immunology; onkologi; cancer; Cytologi; cancerology; oncology; Microarray; Cytology; Mantel cell lymphoma; Immunologi; serologi; Centrocyte;

    Abstract : This thesis covers aspects of the mature human B cell and its different guises on its way to become a fully differentiated antibody forming plasma cell (AFC), the key player in the humoral immune system. The understanding of the complex molecular mechanisms taking place in the B cell, as it first encounters antigen, enters the germinal center (GC) reaction, giving rise to memory cells and plasma cells, is not only of importance for the curious scientist, but will also benefit the understanding of B cells in disease. READ MORE

  6. 4. Mechanistic studies of the adjuvant effects of CTA1-DD and the native cholera toxin: Impact of cell targeting and tissue localization

    Author : Johan Mattsson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Vaccines; adjuvants; cholera toxin; germinal center; CTA1-DD; follicular dendritic cells; denritic cells; Th1; Th2; Th17; complement;

    Abstract : Vaccines are the most effective means of preventing infectious diseases and improving global health. However, few vaccines have successfully been developed for protection at mucosal surfaces where most pathogens gain access. READ MORE

  7. 5. A Search for the Masked Mechanism Behind IgG-Mediated Suppression of Antibody Responses

    Author : Joakim Bergström; Birgitta Heyman; Jenny Hallgren Martinsson; Frida Henningsson Johnson; Mats Bemark; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; FcγR; complement; sheep erythrocytes; IgG-mediated immune suppression; rhesus prophylaxis; rhesus D antigen; germinal center; Immunologi; Immunology;

    Abstract : Antibodies passively administered together with their specific antigen can enhance or suppress the specific antibody response. This phenomenon is known as antibody feedback regulation. Whether this modulation causes up- or downregulation of the antibody response depends both on the antibody isotype and the antigen used. READ MORE