Search for dissertations about: "germinal centers"

Showing result 11 - 15 of 18 swedish dissertations containing the words germinal centers.

  2. 11. Early events of EBV mediated B cell transformation

    Author : Katja Pokrovskaja; Karolinska Institutet; Karolinska Institutet; []
    Keywords : EBV; EBNA; p53; LMP-1; BL; GC; pNDCFs;

    Abstract : Epstein-Barr virus (EBV) efficiently immortalizes B cells in vitro leading to the establishment of lymphoblastoid cell lines (LCLs). Genes encoding RB and p53 are frequently deleted or mutated in human tumors. EBV immortalized LCLs, however, retain both genes in their wild type state. READ MORE

  4. 12. Chemokines and chemokine receptors during viral infections in man

    Author : Frida Mowafi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : B cells; Chemokine receptors; Chemokines; HIV-1; EBV;

    Abstract : Chemokines and chemokine receptors are critical mediators of cell migration during immune surveillance, inflammation and development. The generation of antibody responses depends on B and T cell collaboration within germinal centers in lymphoid tissue. READ MORE

  5. 13. Metab-Immune analysis of the non-obese diabetic mouse

    Author : Viqar Banday; Kristina Lejon; Åsa Andersson; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NOD mouse; Type 1 diabetes; B cells; glutamic acid; metabolomics; immunologi; Immunology;

    Abstract : Type 1A diabetes mellitus or T1D is a chronic disease characterized by T cell mediated destruction of the insulin producing β cells in the islets of Langerhans. The classical symptoms include high glucose levels in urine and blood, polyuria, and polydipsia. READ MORE

  6. 14. Co-stimulation in gut mucosal immunity. Evidence of a differential regulationof local and systemic responses

    Author : Eva Gärdby; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mucosal immunity; PP; cholera toxin; oral immunization; co-stimulation; Th1 Th2;

    Abstract : In recent years we have learned that co-stimulatory factors are required as second signals for optimal T cell stimulation. Most types of immune responses are, therefore, dependent on the co-stimulatory signals that are provided by infection or immunization. READ MORE

  7. 15. On the role of HMGB1 and IL-1 in tissue barrier defense

    Author : Cecilia Zetterström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The specialized epithelial surfaces of the lymphoepithelial tissue in the airways and the seminiferous epithelium of the testis are sites of host-environmental interaction at the same time as they serve important physiological functions in gas exchange and reproduction. The host response of a broken epithelial barrier requires rapid mechanisms to control the microflora and to prevent invasion of pathogens. READ MORE