Search for dissertations about: "gh resistance"

Showing result 1 - 5 of 30 swedish dissertations containing the words gh resistance.

2. 1. Metabolic Effects of Growth Hormone Replacement Therapy in Adults - with Special Reference to Insulin Sensitivity

   Author : Mikael Segerlantz; Malmö Institutionen för kliniska vetenskaper; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetology; secreting systems; Endocrinology; Endokrinologi; sekretion; diabetologi; cortisol replacement; lipid oxidation; glucose metabolism; glucose uptake; insulin resitance; GH; insulin sensitivity; GH deficiency;

   Abstract : A risk for premature atherosclerosis and increased cardiovascular mortality has been reported in adult patients suffering from growth hormone deficiency (GHD) and receiving conventional hormone substitution without growth hormone (GH) replacement. GHD patients are resistant to insulin, which is a potential risk factor for cardiovascular mortality. READ MORE

4. 2. Keratinocyte differentiation. Involvement of the growth hormon (GH)/insulinlike growth factor1 (IGFI) axis and IGF1 post receptor signaling

   Author : Elisabeth Björntorp Mark; Göteborgs universitet; []
   Keywords : IGF1R; GH; Id1; keratinocytes; psoriasis;

   Abstract : At cellular level, little is known about the genes that regulate keratinocyte differentiation andproliferation. Psoriasis is regarded as a T-cell mediated inflammatory disease with hyperproliferativekeratinocytes. READ MORE

5. 3. The growth hormone receptor and growth hormone sensitivity in man

   Author : Ruth Wickelgren; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GH sensitivity; GH receptor; quantitative RT-PCR; IGF-I; skeletal muscle; adipose tissue; tissue-specific; promoter; 5´-untranslated region; psoriasis; epidermis;

   Abstract : It is well established that the response to endogenous and exogenous growth hormone (GH) varies between individuals. For example, conditions with increased catabolic rate, such as trauma, sepsis and surgery, are believed to be associated with acquired GH insensitivity. READ MORE

6. 4. Insulin-like Growth Factor-I (IGF-I) and Interleukin-6 (IL-6) regulate body fat

   Author : Kristina Wallenius; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obesity; insulin-like growth factor I IGF-I ; interleukin-6 IL-6 ; growth hormone GH ; GH releasing factor GHRF ; GH secretagogue GHS ; receptor; leptin; insulin; glucose; intracerebroventricular ICV ; dual-energy X-ray absorptiometry DXA ; indirect calorimetry.;

   Abstract : The aim of this thesis was to investigate the role of insulin-like growth factor-I (IGF-I) and interleukin-6 (IL-6) in the regulation of metabolism and body fat mass. Circulating IGF-I is mainly liver derived, while a large part of circulating IL-6 is produced by adipose tissue. READ MORE

7. 5. GH/IGF-I axis regulation of cardiovascular and neuronal gene expression and function

   Author : Anna Barlind; Göteborgs universitet; []
   Keywords : Growth hormone; rat; hypophysectomy; vascular resistance; gene expression; place learning; Intellicage; hexarelin; CNS; hippocampus; neurogenesis; cell survival; mouse;

   Abstract : Abstract Cardiovascular disease is a major cause of mortality in the Western world. Another important clinical condition is brain damage due to radiation therapy in cancer patients. This has neurological impairments presenting in the survivors. For both these conditions, it is important to develop new therapeutic strategies. READ MORE