Search for dissertations about: "gist"

Showing result 1 - 5 of 13 swedish dissertations containing the word gist.

  1. 1. Gastrointestinal stromal tumours. On diagnosis and treatment

    Author : Per Bümming; Göteborgs universitet.; Gothenburg University.; [2006]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adjuvant; epidemiology; GIST; imatinib; KIT; mutation; neoadjuvant; neuroendocrine phenotype; PET; prognosis; surgery; vesicle proteins;

    Abstract : Gastrointestinal stromal tumours (GIST) are thought to originate from the interstitial cells of Cajal, which show many properties in common with neurons of the gastrointestinal tract. High-risk GIST has a very poor prognosis and tumour recurrence is common after intentionally curative surgery. READ MORE

  2. 2. Pharmacometric Models for Biomarkers, Side Effects and Efficacy in Anticancer Drug Therapy

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Emma K. Hansson; Uppsala universitet.; [2012]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacokinetics; Pharmacodynamics; Oncology; Febrile Neutropenia; GIST; Sunitinib; PHARMACY; FARMACI; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Abstract : New approaches quantifying the effect of treatment are needed in oncology to improve the drug development process and to enable treatment optimization for existing therapies. This thesis focuses on the development of pharmacometric models for biomarkers, side effects and efficacy in order to identify predictors of clinical response in anti-cancer drug therapy. READ MORE

  3. 3. Theoretical studies of protein-ligand binding

    University dissertation from Lund University (Media-Tryck)

    Author : Majda Misini Ignjatovic; Lunds universitet.; Lund University.; [2019-06-05]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Protein-ligand binding; MD; GIST; GCMC; FEP; Solvation; Entropy; Water; QM MM-FEP; Protein-ligand binding; MD; GIST; GCMC; FEP; Solvation; Entropy; Water; QM MM-FEP;

    Abstract : Understanding how drugs work is of great importance, since it can facilitate drug discovery, both time- and costwise. At the same time, it is important to have methods that can help predict how well does a potential drug molecule bind to its target. Computational methods can in many ways contribute to drug design process. READ MORE

  4. 4. Pancreatic Endocrine Tumors and GIST - Clinical Markers, Epidemiology and Treatment

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Sara Ekeblad; Uppsala universitet.; [2007]
    Keywords : Medicine; Pancreatic endocrine tumor; Gastrointestinal stromal tumor; Neuroendocrine; Multiple endocrine neoplasia type 1; Prognostic factors; Temozolomide; TNM staging; O6-methylguanine DNA methyltransferase; Growth hormone secretagogue receptor; Ghrelin; Medicin;

    Abstract : Pancreatic endocrine tumors and gastrointestinal stromal tumors are rare. Evidence regarding prognostic factors, and in the former also treatment, is scarce.We evaluated the survival and prognostic factors in a consecutive series of 324 patients with pancreatic endocrine tumors treated at a single institution. READ MORE

  5. 5. Gastrointestinal stromal tumors. Pathogenetic mechanisms, phenotypic characterization and prognosis

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Johanna Andersson; Göteborgs universitet.; Gothenburg University.; [2005]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gastrointestinal stromal tumor GIST ; neurofibromatosis type I NF1 ; mutation; prognosis; denaturating high performance liquid chromatography dHPLC ; sequencing; KIT; PDGFRA; NF1;

    Abstract : Gastrointestinal stromal tumor (GIST), the most common non-epithelial neoplasm of the gastrointestinal tract, has historically been problematic both conceptually and clinically. Recently, GIST has been shown to share phenotypic features with the interstitial cells of Cajal (ICC), including the almost uniform expression of the tyrosine kinase receptor KIT. READ MORE