Search for dissertations about: "gist"

Showing result 11 - 15 of 19 swedish dissertations containing the word gist.

  2. 11. Translational investigations of novel and current antitumoral therapies in gastrointestinal stromal tumors

    Author : Robin Fröbom; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Gastrointestinal stromal tumor (GIST) is the most common human sarcoma. Its incidence is around 10-15 per million person-years, translating into 150 new cases each year in Sweden. READ MORE

  4. 12. Markers for clinical outcome and therapy response in soft tissue sarcomas

    Author : Jan Åhlen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Soft-tissue sarcomas (STSs) constitute a heterogeneous group of rare but aggressive tumors that originate from mesenchymal cells in almost any part of the body. Gastrointestinal stromal tumor (GIST), located in the gastrointestinal tract, is the most common type of STS. READ MORE

  5. 13. Extracting Text into Meta-Data : Improving machine text-understanding of news-media articles

    Author : Johannes Lindén; Tingting Zhang; Stefan Forsström; Patrik Österberg; Martin Holeňa; Mittuniversitetet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : Society is constantly in need of information. It is important to consume event-based information of what is happening around us as well as facts and knowledge. As society grows, the amount of information to consume grows with it. READ MORE

  6. 14. Therapy of neuroendocrine tumors with 177Lu-octreotate - Human tumor cell types and models and optimization of treatment : Terapi av neuroendokrina tumörer med 177Lu-octreotate

    Author : Johanna Dalmo; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; somatostatin; radionuclide therapy; receptor up-regulation; RBP; nephrotoxicity;

    Abstract : Neuroendocrine (NE) tumors (NET) have often metastasized at the time of diagnose, which makes it hard to cure patients with NET. Radiolabeled hormone analogues (especially somatostatin analogues, SS) can be used for diagnostics (e.g. 111In-octreotide) and therapy (e. READ MORE

  7. 15. Pharmacometrics to improve clinical benefit assessment in oncology

    Author : Emilie Schindler; Lena E Friberg; Mats O Karlsson; Rik de Greef; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nonlinear mixed effect models; NONMEM; pharmacokinetics; pharmacodynamics; VEGF; SLD; targeted therapies; IRT; FDG-PET; SUVmax; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : The high attrition rate in oncology drug development calls for new approaches that would increase the understanding of drugs’ efficacy and safety profiles. This thesis focuses on the development of pharmacometric models to characterize and quantify the relationships between drug exposure, circulating and imaging biomarkers, adverse effects, overall survival (OS), and patient-reported outcomes (PROs). READ MORE