Search for dissertations about: "glia fibrillary acidic protein"

Showing result 1 - 5 of 9 swedish dissertations containing the words glia fibrillary acidic protein.

  2. 1. Studies of cerebral blood flow and cerebrospinal fluid in childhood acute lymphoblastic leukemia

    Author : Gustaf Österlundh; Göteborgs universitet; []
    Keywords : childhood acute lymphoblastic leukemia; methotrexate; neurotoxicity; cerebral blood flow; single photon emission computed tomography; cerebrospinal fluid; neuron-specific enolase; glia fibrillary acidic protein; neurofilament; ascorbyl radical;

    Abstract : Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy and more than 80% of the patients are cured today. Treatment might cause side effects and central nervous system (CNS) irradiation has been replaced by systemic high-dose methotrexate (MTX) and intrathecal (IT) MTX due to the risk of late effects. READ MORE

  4. 2. On age related changes in axons and glia of the central nervous system

    Author : Susanna Kullberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Aging; synaptic input; spinal cord; hippocampus; amino acid neurotransmitters; astrocyte; microglia; oligodendroglia; C bouton; cholinergic; monoaminergic; cytokine;

    Abstract : A growing body of evidence shows that phenotypic changes including axon aberrations, rather than loss of neurons, account for behavioral impairments during aging. The present thesis was undertaken to investigate the occurrence of axon aberrations in relation to transmitter identity, glial reaction and sensorimotor disturbances. READ MORE

  5. 3. Photoreceptor degeneration, second order neuron remodeling and glia reactivity in an in vivo and in vitro model of retinal neurodegeneration

    Author : Tanzina Mollick; Örebro universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicin; Biomedicine;

    Abstract : Photoreceptors have the ability to last during the entire lifespan of an individual. Being the first line of neurons in the visual transduction pathway, their health and maintenance is eminent for proper retinal function. However, photoreceptors are susceptible to neurodegenerative retinal dystrophies. READ MORE

  6. 4. Regulation of neurotrophins and their receptors : molecular aspects and functional implications

    Author : Tuija Salin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : neurotrophin; nerve growth factor; brain-derived neurotrophic factor; neurotrophin-3; neurotrophin-4; glia; gliosis; neuron; tyrosine kinase receptor; transgenic; null mutation; gene; exon; intron; mRNA;

    Abstract : The aim of this work was to study the regulation of neurotrophins and their receptors in a functional aspect. The studies included analysis of neuronal and glial neurotrophin gene expression, that was investigated by using molecular biological techniques. READ MORE

  7. 5. Role of IL-1RAcP and IL-1ra in IL-1 signalling : molecular biological and transgenic studies

    Author : Johan Lundkvist; Alberto Mantovani; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Other chemistry; Övrig kemi;

    Abstract : IL-1 is a proinflammatory cytokine which causes systemic responses such as fever, increased neuroendocrine activity, sympathetic outflow and increased immune responses. Activation of the transcription factor NFkB is one of the molecular mechanisms involved in IL-1 signalling. READ MORE