Search for dissertations about: "glial differentiation"

Showing result 11 - 15 of 87 swedish dissertations containing the words glial differentiation.

  2. 11. Micro-environmental control of tumor differentiation and invasiveness

    Author : Caroline Gélabert; Aristidis Moustakas; Alexander Pietras; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; cell signaling; TGFβ; non-coding RNAs; metabolism;

    Abstract : The transforming growth factor β (TGFβ) family participates in embryonic development and adult tissue homeostasis. In early stages of tumorigenesis, TGFβ promotes cell cycle arrest and apoptosis; however, in advanced malignancies, TGFβ promotes tumor cell migration and metastasis via the induction of epithelial-tomesenchymal transition (EMT). READ MORE

  4. 12. On molecular mechanisms of neural differentiation and forebrain development

    Author : Erik Södersten; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Telencephalic development is an extraordinary complex process where neural structures of highly diverse cell compositions emerge as the result of multiple developmental strategies imposing tight regulation, balance and timing of gene expression. Embryonic telencephalic neural stem cells (NSCs) can form the major cell types found in the telencephalon, and are thus an excellent model for studying transcriptional control of lineage choice mechanisms in CNS development. READ MORE

  5. 13. The role of Nkx proteins neuronal and glial specification

    Author : Anna Vallstedt; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : During development, different classes of neurons and glia are generated from proliferative progenitor cells lining the ventricles of the brain and the lumen of the spinal cord. A central issue in developmental neuroscience is to understand the mechanisms by which these cells are generated in space and over time. READ MORE

  6. 14. Molecular mechanisms for lineage-restricted differentiation of adult neural progenitors

    Author : Muna Elmi; Göteborgs universitet; []
    Keywords : ;

    Abstract : Aims: In the central nervous system of several species, including humans, neurogenesis per?sists even in the adult life in discrete neurogenic regions of the brain. Adult neural stem cells derived from these neurogenic areas are proliferating cells, which can differentiate to neurons, astrocytes, and oligodendrocytes. READ MORE

  7. 15. Genetic Sex Differences in Early Human Neuronal Development : An Investigation in Embryo Tissue and Embryonic Stem Cells

    Author : Philipp Pottmeier; Elena Jazin; Armin Raznahan; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; sex chromosome; gametolog; x y homolog; male; female; sex differences; sex bias; embryonic stem cells; neurodevelopment; neuronal differentiation; neural stem cells; genetics; neurodevelopmental disorders; Biology with specialization in Evolutionary Organismal Biology; Biologi med inriktning mot evolutionär organismbiologi; Neuroscience; Neurovetenskap; Medicinsk genetik; Medical Genetics;

    Abstract : Sex differences in the human body affect many different organs and tissues, some of them have an effect on the human brain and its development. In the developing nervous system, sex differences can bias the number or functionality of neurons, glial cells or synapses. As a result, neural networks might develop with a sex-specific bias. READ MORE