Search for dissertations about: "glial differentiation"

Showing result 16 - 20 of 87 swedish dissertations containing the words glial differentiation.

  2. 16. Cellular Origin and Development of Glioma

    Author : Nanna Lindberg; Lene Uhrbom; Bengt Westermark; Kristian Pietras; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glioma; brain tumor; PDGF; RCAS TV-A; cell of origin; glial cell; oligodendrocyte progenitor cell; DNA repair; homology-directed repair; RAD51; angiogenesis; histidine-rich glycoprotein; Morphology; cell biology; pathology; Morfologi; cellbiologi; patologi; Molecular Medicine; molekylär medicin genetik och patologi ;

    Abstract : Gliomas are the most common primary tumors of the central nervous system believed to arise from glial cells. Invasive growth and inherent propensity for malignant progression make gliomas incurable despite extensive treatment. READ MORE

  4. 17. The many faces of p57Kip2 : acting in apoptosis, differentiation and cytoskeleton reorganisation

    Author : Pinelopi Vlachos; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : p57Kip2 is a known cyclin dependent kinase inhibitor, which has been suggested to be a tumor suppressor gene. Indeed various human cancers show a reduction in p57Kip2 expression, indicating that this protein might be of relevance in tumorigenesis. READ MORE

  5. 18. Stem cell differentiation, plasticity and regenerative mechanisms in the cholinergic system : implications for Alzheimer’s disease

    Author : Mats Nilbratt; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Alzheimer´s disease; amyloid precursor protein; cholinergic differentiation; human embryonic stem cells; neural precursor; nicotinic acetylcholine receptor; neurotrophic factor; radial glial cells; transplantation;

    Abstract : Stem cells are immature cells with self-renewal capacity. They are able to differentiate into multiple lineages that may serve as a source of expandable cells for various applications. READ MORE

  6. 19. Regenerating the brain : stem cell differentiation and cholinergic dysfunction in Alzheimer disease

    Author : Linn Malmsten; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Hippocampal neurogenesis in the adult brain is important for learning and memory processes, which are heavily affected in Alzheimer disease (AD). Thus, targeting processes that could stimulate neurogenesis is a logical step in the search for strategies offering neuronal renewal and brain repair. READ MORE

  7. 20. Intrinsic and extrinsic factors controlling the differentiation of human midbrain progenitor cells

    Author : Nicolaj Christophersen; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; neurotrophic factors; Parkinson s disease; microarray; dopaminergic; Embryonic stem cells; neural stem cells;

    Abstract : Parkinson's disease (PD) is a common neurodegenerative disorder characterized by motor deficits. Levodopa treatment provides marked symptomatic relief. However, within 5-10 years after the start of Levodopa treatment, most PD patients display a gradual loss of drug efficacy. READ MORE