Search for dissertations about: "glial differentiation"

Showing result 21 - 25 of 87 swedish dissertations containing the words glial differentiation.

  2. 21. EMBRYONIC GLIA AND FOREBRAIN NEUROGENESIS; in vitro generation and differentiation of telencephalic neurons

    Author : Charlotta Skogh; Neurobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; beta tubulin III; GFAP; RC2; Neurology; neuropsychology; neurofysiologi; DARPP-32; retinoic acid; serum; EGF; co-culture; cell culture; striatum; LGE; progenitor; precursor; radial glia; region specific; development; CNS; mouse; human; neurophysiology; Neurologi; neuropsykologi;

    Abstract : The current thesis is aimed to increase our understanding of the generation and differentiation of telencephalic neurons, with emphasis on the role of glial cells in these processes. Using in vitro methods we have studied the role of glial cells in neurogenesis, inheritance of genetic regional specification, and influence on differentiation of neurons. READ MORE

  4. 22. Directed differentiation of adult neural stem cells for cell therapy in the nervous system

    Author : Niklas Holmström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The emergence of neural stem cell research has raised hopes for cell therapy of neurological disorders. Insight into the normal mechanisms of neural stem cell fate specification and differentiation is a prerequisite for the development of safe and efficient clinical applications. READ MORE

  5. 23. Calcium signaling in neurogenesis: regulation of proliferation, differentiation and migration of neural stem cells

    Author : Paola Rebellato; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The calcium ion (Ca2+) is a highly versatile and ubiquitous signaling messenger in all cell types. Signal transduction occurs through changes in the cytosolic Ca2+ concentration after the opening of Ca2+ channels in the plasma membrane (PM) and endoplasmic reticulum (ER). READ MORE

  6. 24. Directing stem cells and progenitors towards neuronal differentiation - implications for experimental therapies for Parkinson's disease

    Author : Anke Brederlau; Göteborgs universitet; []
    Keywords : stem cells; Parkinson s disease; progenitors; BMP; ASK1; dopamine;

    Abstract : The insight that stem- and progenitor-cells contribute to replacement of nerve cells in the adult central nervous system is the basis of modern therapies for structural brain repair. Their goal is to protect, support and stimulate endogenous stem cells in areas affected by disease and to replace lost cells by transplanting in vitro generated, tailored nerve cells. READ MORE

  7. 25. In vitro studies on human first trimester forebrain cells : differentiation and interactions with immunoregulating molecules

    Author : Alyaa Mohammed Ali Mousa; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : This thesis has focused on understanding, at the molecular level, growth regulation and differentiation of human first trimester forebrain cells, and the immune signals mediating these processes. Primary cultures were established from human forebrain tissue derived from elective first trimester abortions. READ MORE