Search for dissertations about: "glial fibrillary acidic protein"

Showing result 6 - 10 of 53 swedish dissertations containing the words glial fibrillary acidic protein.

2. 6. Brain parenchymal fraction in healthy individuals and in clinical follow-up of multiple sclerosis

   Author : Mattias Vågberg; Anders Svenningsson; Richard Birgander; Jonathan Gilthorpe; Anne-Marie Landtblom; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Brain parenchymal fraction; Neurofilament light; Glial fibrillary acidic protein; Brain atrophy; Multiple Sclerosis; Clinical follow-up;

   Abstract : Background Multiple sclerosis (MS) is an autoimmune disease characterised by inflammatory damage to the central nervous system (CNS). Accumulated CNS injury can be quantified as brain atrophy, definable as a reduction in brain parenchymal fraction (BPF). BPF correlate with disability in MS and is used routinely as an endpoint in clinical trials. READ MORE

4. 7. Effects of Ischaemia on the Neuroretina and Retinal Blood Vessels

   Author : Bodil Gesslein; Lund Oftalmologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; protein kinase C; tumor necrosis factor; mitogen-activated protein kinases; pig; blood vessels; mfERG; Retinal ischaemia; vascular endothelial growth factor; hypoxia-inducible factor;

   Abstract : Identification of the intracellular signal transduction pathways activated in retinal ischaemia may be important in revealing novel pharmacological targets. The retinal blood vessels are key organs in circulatory failure, and in this work the retinal vasculature was therefore examined separately from the neuroretina. READ MORE

5. 8. Neurofilament light as a marker for neurodegenerative diseases

   Author : Niklas Norgren; Torgny Stigbrand; Roland Carlsson; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; Neurofilament protein; ELISA; Cerebrospinal fluid; Neurodegenerative diseases; Immunologi; Immunology; Immunologi; immunologi; Immunology;

   Abstract : Neurofilaments are the main cytoskeletal constituents in neuronal cells. They are belived to be important for maintaining the structural integrity and calibre of axons and dendrites thereby influencing the conduction velocity of nerve impulses. READ MORE

6. 9. Functional studies of the Quaking gene : Focus on astroglia and neurodevelopment

   Author : Katarzyna Radomska; Elena Jazin; Pertti Panula; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; QKI; RNA-binding protein; astrocyte; interferon; GFAP; neurodevelopment; zebrafish; neural progenitor cell;

   Abstract : The RNA-binding protein Quaking (QKI) plays a fundamental role in post-transcriptional gene regulation during mammalian nervous system development. QKI is well known for advancing oligodendroglia differentiation and myelination, however, its functions in astrocytes and embryonic central nervous system (CNS) development remain poorly understood. READ MORE

7. 10. Disorders of the cerebral white matter in children

   Author : Ragnhildur Kristjánsdóttir; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; leukoencephalopathy - children - neurological impairments - magnetic resonance imaging - ophthalmology - visual evoked potentials - cerebrospinal fluid - sulfatide - glial fibrillary acidic protein - gangliosides - neurofilament - tau protein - monoamine metabolites;

   Abstract : The aims of this thesis were to describe the clinical spectrum in a large group of children characterised as having an abnormal magnetic resonance imaging (MRI) signal from cerebral white matter (WM) and to study the radiological, clinical and ophthalmological features in that subgroup where aetiology was unknown. We also wanted to look at biochemical markers in the cerebrospinal fluid (CSF) to elucidate pathological processes which were responsible for the WM abnormalities. READ MORE