Search for dissertations about: "glial-cell-line-derived-neurotrophic factor"

Showing result 21 - 25 of 41 swedish dissertations containing the words glial-cell-line-derived-neurotrophic factor.

  2. 21. GDNF family ligands and neural stem cells in Parkinson's disease

    Author : Peter Åkerud; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Parkinson's disease (PD) is a very common neurodegenerative disorder, characterized by a progressive degeneration of mainly nigrostriatal and mesolimbic dopaminergic neurons leading to tremor, rigidity and hypokinesia, the classical symptoms of the disease. Degeneration of noradrenergic neurons of the locus coeruleus are also involved in the progression of the disease, causing dementia and depression. READ MORE

  4. 22. Prevention and intervention therapies in auditory trauma

    Author : Anette Fransson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Hearing impairment is one of the most common health conditions in developed countries. It is estimated that approximately 70 million people worldwide are deaf. For patients with a severe to profound hearing loss a cochlear implant (CI) is the only treatment today. READ MORE

  5. 23. Dysfunction in the nigrostriatal system : effects of L-DOPA and GDNF

    Author : Nina Nevalainen; Ingrid Strömberg; Nancy Zahniser; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson’s disease; L-DOPA; dyskinesia; GDNF; dopamine; glutamate; serotonin; medicinsk utvecklings- och neurobiologi; Developmental Neurosciences;

    Abstract : Parkinson’s disease is a common neurodegenerative disorder caused by nigrostriatal dopamine loss, with motor deficiencies as the primary outcome. To increase the striatal dopamine content, patients are treated with 3,4-dihydroxyphenyl-l-alanine (l-DOPA). READ MORE

  6. 24. GDNF gene delivery in an animal model of Parkinson's disease. Long-term effects on intact, injured and transplanted dopamine neurons using lentiviral gene transfer

    Author : Biljana Georgievska; Neurobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurologi; Neurology; neuropsykologi; neurofysiologi; neurophysiology; transplantation; tyrosine hydroxylase; tetracycline; striatum; substantia nigra; sprouting; regulation; neuroprotection; lentivirus; gene therapy; GDNF; behavior; dopamine; neuropsychology;

    Abstract : Parkinson's disease is characterized by a progressive degeneration of dopaminergic neurons in the substantia nigra, leading to a loss of dopamine in the target structure striatum and development of motor symptoms, such as bradykinesia, rigidity and tremor. New experimental treatment strategies for Parkinson's disease are aimed at either preventing the degeneration of the dopaminergic neurons, or at restoring dopamine in the striatum by fetal dopaminergic transplants. READ MORE

  7. 25. Autoimmune and innate inflammation in the nervous system : neurotrophin production and impact on neuronal survival

    Author : Cecilia Lundberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : neurodegeneration; autoimmunity; neurotrophin; motoneuron; cytokine; axotomy;

    Abstract : The occurrence of a continuous immune surveillance in the central nervous system (CNS) is a fairly recent finding. For long the CNS was considered an immune privileged organ, with the blood-brain barrier constituting an effective barrier against blood-derived molecules and cells. READ MORE