Search for dissertations about: "glioblastoma multiforme treatment thesis"

Showing result 16 - 20 of 24 swedish dissertations containing the words glioblastoma multiforme treatment thesis.

2. 16. Neural Progenitor Cells in malignancy and injury of the brain. A Trojan Horse fro gliomas?

   Author : Karin Staflin; CNS Genterapi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; serologi; transplantation; Immunologi; Medicine human and vertebrates ; Medicin människa och djur ; Immunology; serology; Glioma; sub ventricular zone; neural progenitor cell;

   Abstract : Gliomas are neoplasms arising in the central nervous system (CNS), and constitute the most common primary brain tumor. They are classified depending on the grade and morphology, from grade I, pilocytic astrocytoma, to grade IV, glioblastoma multiforme (GBM). Glioblastomas constitute a great challenge in treatment due to their disseminating nature. READ MORE

4. 17. Myeloid cells in experimental neuropathologies

   Author : Melanie Pieber; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The first innate immune cells, most importantly for this thesis macrophages, microglia and eosinophils, were described more than 100 years ago and only now do we begin to understand more about their development, functions and properties. So while elimination of pathogens through phagocytosis (macrophages/microglia) or degranulation (eosinophils) were long considered as their main functions, research during the last decades has made it clear that innate immune cells do much more than maintain homeostasis in an organism. READ MORE

5. 18. Regulation of ongoing DNA synthesis in normal and neoplastic brain tissue

   Author : Juan Sebastián Yakisich; Karolinska Institutet; Karolinska Institutet; []
   Keywords : DNA replication - Cell cycle - Brain - Gliomas - Tissue mini-unit - Protein kinases - Proteases Inhibitors - Roscovitine;

   Abstract : The treatment of human brain tumour is challenging in part due to the blood brain barrier and in part due to the specific biology of brain tumours that confer resistance to chemotherapy. For instance, the 5 years survival rate for patients carrying intracranial glioblastoma multiforme has remained at 4-5 % for the last 30 years. READ MORE

6. 19. Role of TGFβ-induced hyaluronan-CD44 signaling in cancer progression

   Author : Constantinos Kolliopoulos; Evi Heldin; Aristidis Moustakas; Jonathan Sleeman; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hyaluronan; CD44; TGFβ; cancer; EMT; signal transduction; transcriptional regulation;

   Abstract : Hyaluronan, a prevalent glycosaminoglycan of the extracellular space often accumulates in pathological conditions, such as chronic inflammation, infection, and cancer. Hyaluronan synthase HAS2 has been responsible for the synthesis and deposition of hyaluronan in a variety of tumors. READ MORE

7. 20. Experimental brain tumors, dendritic cells and immunotherapy

   Author : Shorena Janelidze; Neurokirurgi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dendritic cell; interferon-γ; immunotherapy; Brain tumor;

   Abstract : Malignant astrocytomas are the most common primary tumors of the adult central nervous system. Surgical resection of tumor mass in combination with radiotherapy and chemotherapy is only palliative and there is a clear need for new and more effective therapeutic strategies. READ MORE