Search for dissertations about: "glioblastoma"
Showing result 21 - 25 of 144 swedish dissertations containing the word glioblastoma.
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21. CAR T cells for Immunotherapy of Cancer
Abstract : In recent years, immunotherapy has revolutionized cancer treatment by prolonging survival and even curing patients lacking other available therapies. Besides immune checkpoint inhibitors, one of the major advances is attributed to the success of chimeric antigen receptor (CAR)-T cell therapy in treating patients with B-cell malignancies. READ MORE
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22. Mechanistic Studies On the Role of Polyamines and Microvesicles in Tumor Growth and Hypoxia-mediated Angiogenesis
Abstract : Solid tumors are composed of cancer cells, as well as resident or infiltrating non-malignant cells that contribute to the malignant state in an ecosystem generally accepted as the tumor microenvironment. Microenvironmental tumor hypoxia is the foremost leading cause of angiogenesis, i.e. READ MORE
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23. Statistical Inference on Interacting Particle Systems
Abstract : Interacting particle systems, and more specifically stochastic dynamical systems, is a mathematical framework which allows for condensed and elegant modelling of complex phenomena undergoing both deterministic and random dynamics. This thesis is concerned with the topic of statistical inference on large systems of interacting particles, with the specific application of in vitro migration of cancer cells. READ MORE
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24. Application of Genomic and Expression Arrays for Identification of new Cancer Genes
Abstract : Copy number variation (CNV) comprises a recently discovered kind of variation involving deletion and duplication of DNA segments of variable size, ranging from a few hundred basepairs to several million. By altering gene dosage levels or disrupting proximal or distant regulatory elements CNVs create human diversity. READ MORE
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25. Epigenetics of paediatric glioma stem cells; focusing on exosomes, miRNAs and DNA methylation
Abstract : Tumours in the central nervous system are accountable for the majority of cancer-related deaths in children. Glioblastoma multiforme, one of the deadliest of the central nervous system tumours, is partly driven by glioma stem cells. The generation and maintenance of these cells is orchestrated by complex genetic and epigenetic mechanisms. READ MORE