Search for dissertations about: "glioma stem cells"
Showing result 1 - 5 of 34 swedish dissertations containing the words glioma stem cells.
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1. Stem and progenitor cells in brain ad breast malignancies
Abstract : Stem cells have qualities that clearly distinguish them from all other cells. Capabilities like self-renewal, differentiation and migration make them truly powerful. This thesis deals with different aspects of stem/progenitor cells in relation to cancer. READ MORE
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2. Epigenetics of paediatric glioma stem cells; focusing on exosomes, miRNAs and DNA methylation
Abstract : Tumours in the central nervous system are accountable for the majority of cancer-related deaths in children. Glioblastoma multiforme, one of the deadliest of the central nervous system tumours, is partly driven by glioma stem cells. The generation and maintenance of these cells is orchestrated by complex genetic and epigenetic mechanisms. READ MORE
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3. Modeling Neural Stem Cell and Glioma Biology
Abstract : This thesis is focused on neural stem cell (NSC) and glioma biology. I discuss how NSCs interact with extracellular matrix (ECM) proteins in the stem cell niche, and investigate the consequences of deregulated Platelet-derived growth factor (PDGF) signaling for embryonic NSCs in transgenic mice. READ MORE
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4. Stem cell based therapy of malignant brain tumors
Abstract : Malignant brain tumor is a highly invasive and vascularized cancer. Current forms of therapy are not curative and can, at best, prolong survival for patients with this disease. The mean survival is only around 15 months. READ MORE
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5. Neural Stem and Progenitor Cells : Cellular Responses to Known and Novel Factors
Abstract : Neural stem cell self-renewal and differentiation are tightly regulated events during CNS development, leading to cell division into new neural stem cells or the formation of neurons and glial cells. This thesis focuses on the cellular responses induced by known and novel factors in neural stem and progenitor cells (NSPCs). READ MORE