Search for dissertations about: "glioma"

Showing result 6 - 10 of 180 swedish dissertations containing the word glioma.

  2. 6. Molecular and Cellular Complexity of Glioma : Highlights on the Double-Edged-Sword of Infiltration Versus Proliferation and the Involvement of T Cells

    Author : Demet Çağlayan; Bengt Westermark; Maria Ferletta; Ana Martin-Villalba; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glioma; Sox2; Sox21; Snail; Bone morphogenetic protein; Sleeping Beauty; Gliomatosis Cerebri; T lymphocytes; T regulatory lymphocytes; Oncology; Onkologi; Biology; Biologi;

    Abstract : Glioblastoma multiforme (GBM), the most common and malignant brain tumor, is characterized by high molecular and cellular heterogeneity within and among tumors. Parameters such as invasive growth, infiltration of immune cells and endothelial proliferation contribute in a systemic manner to maintain the malignancy. READ MORE

  4. 7. Risk and prognostic factors for malignant glioma

    Author : Sara Sjöström; Beatrice S Melin; Ulrika Andersson; Monika Hegi; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glioma; Glioblastoma; Risk; Outcome; EGR; EGFR; VEGF; VEGFR; DNA repair; virus; Oncology; Onkologi; onkologi; Oncology;

    Abstract : Background: Glioblastoma is the most common and aggressive type of glioma and associated with poor prognosis. Apart from ionizing radiation and some rare genetic disorders, few aetiological factors have been identified for primary brain tumours. READ MORE

  5. 8. Modeling Neural Stem Cell and Glioma Biology

    Author : Tobias Bergström; Karin Forsberg-Nilsson; Staffan Johansson; Sven Påhlman; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neural stem cell; integrins; glioma; PDGF; mast cell; Molekylär cellbiologi; Molecular Cellbiology; Oncology; Onkologi;

    Abstract : This thesis is focused on neural stem cell (NSC) and glioma biology. I discuss how NSCs interact with extracellular matrix (ECM) proteins in the stem cell niche, and investigate the consequences of deregulated Platelet-derived growth factor (PDGF) signaling for embryonic NSCs in transgenic mice. READ MORE

  6. 9. Experimental studies on glioma cell motility and proliferation

    Author : Adila Salih El-Obeid; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; glioma; TGF-α; EGFR; GFAP; motility; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Abstract : Glioma is a malignant primary brain tumor associated with short patient survival. Various growth factors and cytoskeletal proteins are correlated to glioma progression. In this thesis the effects of transforming growth factor alpha (TGFα) and glial fibrillary acidic protein (GFAP) were studied. READ MORE

  7. 10. Roles of p16INk a and PDGF-B in glioma

    Author : Lene Uhrbom; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; autocrine; glioma; INK4a; PDGF; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Abstract : Gliomas are diffuse astrocytic tumors of the central nervous system (CNS) which usually affect adults. This thesis work has focused on molecular mechanisms of altered growth control in glioma, and the significance of two gene products belonging to pathways commonly affected in glioma, p16INK4a and PDGF-B, has been investigated in vitro and in vivo. READ MORE