Search for dissertations about: "glomeruli"

Showing result 21 - 25 of 38 swedish dissertations containing the word glomeruli.

  2. 21. Type IV collagen : regulation of COL4A1 and COL4A2 genes and gene therapy of Alport syndrome

    Author : Pirkko Kortteinen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : adenovirus; Alport syndrome; basement membrane; bidirectional promoter; collagen; gene regulation; gene therapy; promoter analysis; kidney gene transfer; organ perfusion; type IV collagen;

    Abstract : Type IV collagen is an important structural protein in basement membranes, which am thin sheet-like structures located between organized tissues and the connective tissue. Type IV collagen is composed of six genetically different [alpha] chains. READ MORE

  4. 22. Role of new podocyte-associated proteins in the renal ultrafiltration barrier

    Author : Angelina Schwarz; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Chronic kidney disease (CKD) is a major health problem and an economical burden affecting people worldwide. The main causes of CKD are diabetes and hypertension and patient numbers keep increasing. READ MORE

  5. 23. Functional and molecular aspects of the glomerular barrier

    Author : Anna Björnson Granqvist; Göteborgs universitet; []
    Keywords : glomerular endothelium; glycocalyx; podocyte; proteoglycan; glycosaminoglycans; nephrotic syndrome;

    Abstract : The kidneys are crucial for maintaining a normal salt-water balance in the body, which is a prerequisite for life. They do that by filtering 180 liters of plasma per day across the highly permselective glomerular barrier and reabsorbing 99 % of the filtrate. READ MORE

  6. 24. Genetic basis of congenital nephrotic syndrome and generation of an animal model

    Author : Heli Putaala; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Congenital nephrotic syndrome, NPHS1, is a disease highly enriched in Finland with incidence of 1:8200 births. The disease is characterized by massive proteinuria, go % of which is albumin, starting in utero, large placenta, which weighs over 25 % of the child's birth weight, and manifestation of proteinuria soon after birth. READ MORE

  7. 25. Proteome studies, with emphasis on the kidney glomerulus

    Author : Sam Tryggvason; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Proteomics aims to link genes to protein expression and function. Proteomics is a very versatile and technology-dependent discipline and the development of mass spectrometry-based proteomics has advanced the understanding of the complex and dynamic nature of proteomes. READ MORE