Search for dissertations about: "glucocorticoid receptor"

Showing result 1 - 5 of 89 swedish dissertations containing the words glucocorticoid receptor.

  1. 1. Glucocorticoid receptors in severe inflammation Experimental and clinical studies

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Maria Bergquist; Göran Hedenstierna; Christian Rylander; Catharina Lindholm; Cecile Martijn; Djillali Annane; [2014]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glucocorticoid receptor; sepsis; inflammation; flow cytometry; Klinisk immunologi; Clinical Immunology;

    Abstract : Septic shock is one of the most common causes of mortality in intensive care, in spite of antibiotic treatment. Glucocorticoid treatment can be used to blunt an overwhelming immune response in severe inflammation. READ MORE

  2. 2. Studies of glucocorticoid receptor interacting proteins

    University dissertation from Stockholm : Karolinska Institutet, Department of Medical Nutrition

    Author : Christina Widén; Karolinska Institutet.; Karolinska Institutet.; [2005]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The glucocorticoid receptor (GR) functions as a ligand dependent transcription factor. Nonliganded GR resides mainly in the cytoplasm bound to a complex containing heat shock proteins (hsp). READ MORE

  3. 3. Estrogen and Glucocorticoid Metabolism

    University dissertation from Umeå : Institutionen för Folkhälsa och Klinisk Medicin

    Author : Therése Andersson; Tommy Olsson; Cecilia Mattsson; Ingegerd Söderström; Jonas Burén; Agneta Holmäng; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; 11β-Hydroxysteroid Dehydrogenase Type 1; Estrogen; Cortisol; Adipose tissue; Liver; Menopause; Ovariectomy; Adipocyte; Estrogen Receptor β; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Internal medicine Endocrinology; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Invärtesmedicin Endokrinologi; medicin; Medicine;

    Abstract : Background: Cardiovascular disease (CVD) is the leading cause of death among women in Sweden. The risk of CVD increases rapidly after the menopause. A major contributing factor may be the redistribution of adipose tissue, from the peripheral to central depots, associated with menopause. READ MORE

  4. 4. Interaction of Xenobiotics with the Glucocorticoid Hormone System in vitro

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Maria Johansson; Helen Håkansson; [2002]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biology; DDT; PCB; tolylfluanid; adrenal; CYP11B1; glucocorticoid receptor; endocrine disrupter; Biologi; NATURAL SCIENCES Biology; NATURVETENSKAP Biologi; Ecotoxicology; ekotoxikologi;

    Abstract : Persistent environmental pollutants were examined for their interaction with the glucocorticoid hormone system. The focus was placed on interference with the glucocorticoid synthesis and the glucocorticoid-signalling pathway in various in vitro test systems. READ MORE

  5. 5. Glucocorticoid receptor function; interactions, mutants and ligand responses

    University dissertation from Stockholm : Karolinska Institutet, Biosciences and Nutrition

    Author : Erik Hedman; Karolinska Institutet.; Karolinska Institutet.; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glucocorticoid receptor; glucocorticoids; cross-talk; GR interacting proteins; Flt3; mass spectrometry; 2D gel electrophoresis;

    Abstract : The protein that is investigated in this thesis is the glucocorticoid receptor (GR), which belongs to the nuclear hormone receptor superfamily of ligand activated transcription factors. The nuclear receptors share three conserved structural domains, the N-terminal transactivating domain, the central DNA-binding domain and the C-terminal ligand-binding domain. READ MORE